Results 251 to 260 of about 137,826 (378)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data. [PDF]

Life Sci Alliance
Valieris R, Rosa L, Martins L, Defelicibus A, Carraro DM, Nunes DN, Dias-Neto E, Rosales R, da Silva IT.   +8 more
europepmc   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Interaction between ENPP1 and homologous recombination deficiency defines distinct pan-cancer signatures: A retrospective observational study. [PDF]

Medicine (Baltimore)
Kim YM, Lee SH, Na W, Lee IJ, Kwon M, Jo O, Song YS.   +6 more
europepmc   +1 more source

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.

Cancer Discovery, 2015
P. Konstantinopoulos, Raphael Ceccaldi, G. Shapiro, A. D’Andrea   +3 more
semanticscholar   +1 more source

Comprehensive genomic profiling for homologous recombination deficiency guides PARP inhibitor therapy recommendations in ovarian cancer. [PDF]

Pathol Oncol Res
Inci A, Witzel I, Moch H, Rahmani-Khajouei S, Zoche M, Samartzis EP.   +5 more
europepmc   +1 more source

Constitutional BRCA1 Methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer

Justine Pasanisi, Constance Lamy, Lolita Lecompte, Sophie Vacher, Mathias Schwartz, Abderaouf Hamza, Sandrine M Caputo, Sabrina Ibadioune, Laura Courtois, Frédéric Berger, Vincent Cockenpot, Sylvain Baulande, J-Y Pierga, Céline Callens, Samia Melaabi, Chrystelle Colas, Hilde Brems, Maud Kamal, C. Dupain, Nicolas Servant, C. Le Tourneau, Bièche Ivan   +21 more
openalex   +1 more source

The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer. [PDF]

Oncologist
Jiang B, Shang Y, Zhang X, He W, Hua H, Ye F, Zhou X, Li Y, Zhong W, Jiang W, Wu G.   +10 more
europepmc   +1 more source

Stratification of Homologous Recombination Deficiency-Negative High-Grade Ovarian Cancer by the Type of Peritoneal Spread into Two Groups with Distinct Survival Outcome

Simon Schnaiter, Esther Schamschula, Juliane Laschtowiczka, Heidi Fiegl, Johannes Zschocke, Alain G. Zeimet, Katharina Wimmer, Daniel Reimer   +7 more
openalex   +2 more sources

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source