Results 291 to 300 of about 137,826 (378)

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Unraveling Homologous Recombination Deficiency in Ovarian Cancer: A Review of Currently Available Testing Platforms. [PDF]

Cancers (Basel)
Marconato N, Tommasi O, Paladin D, Boscarino D, Spagnol G, Saccardi C, Maggino T, Tozzi R, Noventa M, Marchetti M.   +9 more
europepmc   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Comprehensive assessment of homologous recombination deficiency via simultaneous methylation and mutation analysis in epithelial ovarian cancer: implications for PARP inhibitors efficacy. [PDF]

Biomark Res
Dong L, Wu H, Li N, Li W, Song Y, Xiong Y, Yin H, Fang H, Chen R, Yi X, Huang J, Ying J.   +11 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Phylogeny, species delimitation and machine learning bridge the gap between DNA sequences and morphology in the lichen genus Arctomia (Arctomiaceae, Ascomycota)

TAXON, EarlyView.
Abstract This study investigates species boundaries in the lichen genus Arctomia (Arctomiaceae, Ascomycota) using an integrative approach combining molecular phylogenetics, full Bayesian population delimitation, heuristic and model‐based species delimitation, and supervised machine learning applied to morphological data.
Stefan Ekman, Måns Svensson, Martin Westberg   +2 more
wiley   +1 more source

101P Homologous recombination deficiency testing in ovarian cancer: Challenges, insights, and clinical implications

Prachi Gogte, U. Shetty, Mamta Gurav, A. Arora, Abhishek Juneja, Bharat Rekhi, Santosh Menon, Trupti Pai, Jaya Ghosh, Amita Maheshwari, Niranjan S. Karnik, Gautam A. Deshpande, Pallav L. Shah, Omshree Shetty, T. Shet   +14 more
openalex   +2 more sources

Clinical Characteristics and Survival of Ovarian Cancer Patients According to Homologous Recombination Deficiency Status. [PDF]

Cancers (Basel)
Sisman Y, Schejbel L, Schnack TH, Høgdall C, Høgdall E.   +4 more
europepmc   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source