Results 311 to 320 of about 137,826 (378)

Refining the Vertebrate Mitochondrial 12S rRNA Secondary Structure by Comparative Analysis

Integrative Zoology, EarlyView.
This flowchart outlines the comprehensive workflow of the study, integrating diverse bioinformatics tools (e.g., NCBI2GO, SSU‐align, bpRNA) and their sequential interactions. Key steps, such as data preprocessing, structural prediction, and evolutionary analysis, are depicted with their respective outputs (e.g., standardized records, consensus ...
Fengxia Li, Gengyun Niu, Renzeng Du, Kun Wan, David Roy Smith, Meicai Wei, Haihe Shi   +6 more
wiley   +1 more source

Long non-coding RNAs as a biomarker for homologous recombination deficiency and parp inhibitor sensitivity in high-grade serous ovarian cancers. [PDF]

Commun Biol
Doberstein K, Panther J, Hahnen E, Richters L, Schouten PC, Harter P, Heitz F, Kommoss S, Berlit S, Tuschy B, Sütterlin M, Marmé F.   +11 more
europepmc   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, EarlyView.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source

Combination of <i>BRCA</i> deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer. [PDF]

Front Oncol
Nguyen Hoang TP, Tran NHB, Nguyen TA, Ngo MTT, Doan AD, Nguyen DQ, Tang HS, Nguyen DS, Thi CTN, Thi TTD, Nguyen HN, Giang H, Tu LN.   +12 more
europepmc   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer. [PDF]

JCO Precis Oncol
Christinat Y, Labidi-Galy I, Ho L, Clément S, Genestie C, Sehouli J, Cinieri S, Gonzalez-Martin A, Kolovetsiou-Kreiner V, Fujiwara K, Von Gorp T, Tognon G, Hietanen S, Heinzelmann-Schwarz V, Ray-Coquard I, Pujade-Lauraine E, McKee TA.   +16 more
europepmc   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data. [PDF]

Mol Oncol
Zhu R, Eason K, Chin SF, Edwards PAW, Manzano Garcia R, Moulange R, Pan JW, Teo SH, Mukherjee S, Callari M, Caldas C, Sammut SJ, Rueda OM.   +12 more
europepmc   +1 more source

Supplementary Table S10 from Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency

Antoine Simoneau, Charlotte B. Pratt, Hsin‐Jung Wu, Shreya S. Rajeswaran, Charlotte Grace Comer, Sirimas Sudsakorn, Wenhai Zhang, Shangtao Liu, Samuel R. Meier, Ashley H. Choi, Tenzing Khendu, Hannah Stowe, Binzhang Shen, Douglas A. Whittington, Yingnan Chen, Yi Yu, William D. Mallender, Tianshu Feng, Jannik N. Andersen, John P. Maxwell, Scott Throner   +20 more
openalex   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source