Results 331 to 340 of about 137,826 (378)

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Evaluation of two algorithms measuring homologous recombination deficiency status in prognostic assessment for treatment-naïve non-small cell lung cancer. [PDF]

Chin J Cancer Res
Ma Y, Huang J, He L, Du J, Liu L, Li X, Jiao P, Wu X, Zhou W, Xu X, Yang L, Di J, Zhu C, Li L, Liu D, Wang Z.   +15 more
europepmc   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines. [PDF]

Cancer Res Commun
Dodson AE, Shenker S, Sullivan P, Nayak SU, Middleton C, McGuire M, Chipumuro E, Mishina Y, Tobin ER, Cadzow L, Wylie AA, Sangurdekar D.   +11 more
europepmc   +1 more source

HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data. [PDF]

Cancer Res
Abbasi A, Steele CD, Bergstrom EN, Khandekar A, Farswan A, McKay RR, Pillay N, Alexandrov LB.   +7 more
europepmc   +1 more source

Results from a Phase 2 Study of Induction Docetaxel and Carboplatin Followed by Maintenance Rucaparib in the Treatment of Patients with Metastatic Castration-resistant Prostate Cancer with DNA Homologous Recombination Repair Deficiency

Ruben Raychaudhuri, Heather H. Cheng, Roman Gulati, Michael T. Schweizer, Aaron Lin, Todd Yezefski, Hiba Khan, Evan Y. Yu, Jessica E. Hawley, Peter S. Nelson, Colin C. Pritchard, Bruce Montgomery   +11 more
openalex   +2 more sources

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer. [PDF]

Front Mol Biosci
Nogueira Rodrigues A, Souto AKBA, de Andrade DAP, Gomes LM, Koide SS, E Silva RG, de Souza BB, Massaro JD, de Melo AC, Borges AM, Giro C, de Andrade CAV, da Costa CM, Gimenes DL, de Mello ECB, de Oliveira FC, Lima FMT, Lopes GL, Bretas GO, Jacob GG, Silva HLDC, Notaro JF, Alves LL, Moitinho MV, da Silva MC, Abramoff R, Rauber TADC, Dienstmann R, Koyama FC.   +28 more
europepmc   +1 more source

Data Sheet 3_EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration.pdf

Runa Sugiyama (22617761), Anna S. Sedukhina (22617764), Eri Sato (3353912), Ayako Yamaura (22617770), Kimino Minagawa (13006248), Sookhee Pae (22617773), Ena Imai (22617776), Ankita Chawla (11652879), Ziran Xu (3226602), Mihika Chakraborty (22617779), Satori Gonoi (22617815), Jotaro Yamaoka (22617818), Kazuo Yudo (22617821), Koichiro Tsugawa (697601), Ko Sato (697604)   +14 more
openalex   +1 more source

Routine Tumor Testing for Homologous Recombination Deficiency in Patients With High Grade Epithelial Ovarian Cancer at a Statewide Gynecological Cancer Service in Western Australia: An Observational Study. [PDF]

Cancer Rep (Hoboken)
Planisamy K, Ctori E, Amanuel B, Allanson ER, Ayres C, Buck M, Howard G, Leung Y, Meniawy T, Mohan GRKA, Nichols CB, Pallayoor ND, Cohen PA.   +12 more
europepmc   +1 more source

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Assessment of Homologous Recombination Deficiency in Ovarian Cancer.

Clinical Cancer Research, 2023
Accurately assessing homologous recombination deficiency to use as predictive biomarker is an area of intense research in ovarian cancer. Validated assays have demonstrated utility in determining maintenance therapy following platinum sensitive ...
V. Garg, A. Oza
semanticscholar   +3 more sources