Results 41 to 50 of about 66,200 (304)
BMC Genomics, 2018 While autozygosity as a consequence of selection is well understood, there is limited information on the ability of different methods to measure true inbreeding.
M. Forutan +5 more
semanticscholar +1 more source
PLoS ONE, 2017 Domestication and the subsequent selection of animals for either economic or morphological features can leave a variety of imprints on the genome of a population.
D. Purfield +3 more
semanticscholar +1 more source
Solyntus, the New Highly Contiguous Reference Genome for Potato (Solanum tuberosum)
G3: Genes, Genomes, Genetics, 2020 With the rapid expansion of the application of genomics and sequencing in plant breeding, there is a constant drive for better reference genomes. In potato (Solanum tuberosum), the third largest food crop in the world, the related species S.
Natascha van Lieshout +10 more
doaj +1 more source
HomozygosityMapper--an interactive approach to homozygosity mapping [PDF]
Nucleic Acids Research, 2009 Homozygosity mapping is a common method for mapping recessive traits in consanguineous families. In most studies, applications for multipoint linkage analyses are applied to determine the genomic region linked to the disease. Unfortunately, these are neither suited for very large families nor for the inclusion of tens of thousands of SNPs. Even if less
Dominik Seelow +3 more
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Only ∼5% of individuals infected with Mycobacterium tuberculosis develop clinical TB in their lifetime. We previously reported that homozygosity for the P1104A variant of the TYK2 gene, found in ∼1/600 Europeans and ∼1/5,000 individuals from
G. Kerner +10 more
semanticscholar +1 more source
Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.
Journal of the American Medical Association (JAMA), 2020 Importance Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but risks are unclear ...
J. Atkins +6 more
semanticscholar +1 more source
Pedigree-Based Description of Danubia Alba Rabbit Breed Lines
AnimalsThe diversity of livestock animal breeds is an integral part of global biodiversity and requires careful management for sustainability and future availability. Avoiding inbreeding is a crucial aspect of mating of breeding animals.
János Posta +5 more
doaj +1 more source
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
Nature MedicineThis study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD.
J. Fortea +13 more
semanticscholar +1 more source
Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs
Genetics Selection Evolution, 2023 Background In spite of the availability of single nucleotide polymorphism (SNP) array data, differentiation between observed homozygosity and that caused by mating between relatives (autozygosity) introduces major difficulties.
Katherine D. Arias +4 more
doaj +1 more source
Facial attractiveness is only weakly linked to genome–wide heterozygosity
Frontiers in Psychology, 2023 IntroductionIt has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances/ pathogens ...
Martin Fieder +2 more
doaj +1 more source