Results 91 to 100 of about 43,378 (245)

Modification of dominance by selection in the homozygote [PDF]

Heredity, 1972
J N, Thompson, J M, Thoday
openaire   +2 more sources

Endemic but not eroded: Genomic distinctiveness and conservation genomics of the British swallowtail butterfly (Papilio machaon britannicus)

Insect Conservation and Diversity, EarlyView.
Through whole‐genome sequencing of P. machaon populations across Europe, we demonstrate that P. m. britannicus forms a genetically distinct and isolated lineage. Demographic modelling revealed weak historical gene flow from the continent. Although P. m.
Benoit Nabholz, Eliette L. Reboud, Bérénice J. Lafon, Adam M. Cotton, Martin G. Partridge, N. Mark Collins, Fabien L. Condamine   +6 more
wiley   +1 more source

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of selection.
Simona Antonios, Jana Obšteter, Ivan Pocrnic, Gregor Gorjanc, Silvia T. Rodríguez‐Ramilo, Zulma G. Vitezica   +5 more
wiley   +1 more source

A case of maturity‐onset diabetes of the young with a pathogenic HNF1A variant and a coexisting NEUROD1 variant

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Maturity‐onset diabetes of the young (MODY) accounts for at least 1%–5% of diabetes cases and is usually caused by single gene variants. Accurate diagnosis of MODY is important for effective management, especially in young individuals who are lean and lack islet autoantibodies.
Tomofumi Takayoshi, Yushi Hirota, Kenji Sugawara, Aki Sugano, Mika Ohta, Takehito Takeuchi, Akane Yamamoto, Wataru Satake, Yutaka Takaoka, Wataru Ogawa   +9 more
wiley   +1 more source

ATXR5 and ATXR6 restrict meiotic crossover formation within heterochromatin in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis H3K27 mono‐methyltransferases ATXR5 and ATXR6 repress crossovers within meiotic heterochromatin, are required for heterochromatin condensation and H3K27me1 establishment, and specifically influence the maintenance of DNA methylation in meiocytes.
Jun Zhang, Yue Yu, Han Wang, Meiling Li, Dingning Li, Chenjiang You, Yingxiang Wang, Cong Wang   +7 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

The consequences of partial clonality on the spatiotemporal genetic structure of the red alga Chondria tumulosa (Ceramiales, Rhodophyta)

Journal of Phycology, EarlyView.
Abstract The relative rates of sexual versus clonal reproduction partition genetic diversity, but the quantification of these rates remains limited in natural populations. This knowledge gap is particularly acute among tropical macroalgae. Chondria tumulosa is a red macroalga that has been documented at high abundance in the three northernmost atolls ...
Taylor M. Williams, Heather L. Spalding, Solenn Stoeckel, Brian B. Hauk, Jonathan Plissner, Randall K. Kosaki, Stacy A. Krueger‐Hadfield   +6 more
wiley   +1 more source

Full‐length coding sequence analysis of the voltage‐gated sodium channel and acetylcholinesterase genes reveals target‐site mutations and acetylcholinesterase gene duplication in housefly (Musca domestica) populations in Japanese livestock barns

Medical and Veterinary Entomology, EarlyView.
We simultaneously analysed insecticide resistance mutations in VGSC and AChE using NGS and hybridization probe capture in houseflies collected from livestock facilities for the first time. Resistance mutations in both VGSC and AChE were detected in most wild populations, suggesting widespread distribution of resistance genes.
Mikie Nakagawa, Kentaro Itokawa, Nozomi Uemura, Yasuhiro Tomioka, Tsutomu Tanikawa, Kyo Itoyama, Shinji Kasai, Osamu Komagata   +7 more
wiley   +1 more source

Cross‐ploidy hybridisation in Alpine woodrushes is associated with ecological additivity and scale‐dependent niche divergence

New Phytologist, EarlyView.
Genetic differentiation among the study species. Summary Hybridisation and whole‐genome duplication (WGD) are widespread in plants, yet their ecological consequences remain challenging to predict. In allopolyploids, where both processes coincide, ecological divergence is typically evaluated against a null hypothesis of ecological additivity.
Valentin Heimer, Peter Schönswetter, Božo Frajman   +2 more
wiley   +1 more source

Structural Variations Contribute to Subspeciation and Yield Heterosis in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Yield heterosis has been extensively exploited in hybrid breeding, with intersubspecific hybrids often exhibiting the most pronounced effects. However, developing elite hybrids remains a laborious and time‐consuming process. The genetic basis of heterosis has been debated for over a century, hindered largely by the lack of high‐quality genomes.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley   +1 more source