Results 81 to 90 of about 164,878 (307)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Study of the Roots of the Egyptian 2011 Revolution According to the Ontological Security Model [PDF]
Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2015 Egyptian revolution in January 2011 was a transition period of the Islamic awakening in the Egypt and therefore it is essential to understand these events.
Javad Mamaghani
doaj
Honor, religion and reputation : the worldview of the German Subsidientruppen who fought in the American War of Independence [PDF]
, 2014 Access to thesis permanently restricted to Ball State community only.Access to abstract permanently restricted to Ball State community only.Thesis (M.A.)Department of HistoryA brief summary of wartime service -- To a man, fighting like heroes -- We are ...
Burns, Alexander S.
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Honor Fell to Viktor Hamburger, February 23, 1938 [PDF]
, 1938 Honor Fell writes to Hamburger to thank him for sending a reprint and is delighted by Hamburger's future work1 ...
Fell, Honor Bridget (1900-1986)
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Revista de Dialectología y Tradiciones Populares, 2014 El artículo muestra cómo en la España de la segunda mitad del siglo XIX el discurso de la estabilidad social y de la sumisión femenina —también llamado de la «domesticidad»— se asienta en el teatro a través de la representación de temas como el honor, el
Francisco Checa Olmos +1 more
doaj +1 more source
Testimonial Dinner to Honor Brooks Hays program - Page 1 [PDF]
, 1958 Program from the Testimonial Dinner to Honor Brooks Hays at the Willard Hotel BallroomTestimonial Dinner To Honor BROOKS HAYS Member of Congress from Arkansas President of Southern Baptist Convention
The National Committee to Honor Hays, Brooks
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source