Results 31 to 40 of about 149,371 (253)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Drivers for Clustering and Inter-Project Collaboration—A Case of Horizon Europe Projects

Administrative Sciences
This paper investigates the drivers and dynamics of clustering and inter-project collaboration within the framework of the Horizon Europe and Horizon 2020 projects.
Takwa Benissa, Anish Patil
doaj   +1 more source

Il finanziamento Venture Capital: implicazioni della definizione di Piccola e Media Impresa

Argomenti: Rivista di Economia, Cultura e Ricerca Sociale, 2021
Questo lavoro analizza la definizione di Piccola e Media Impresa (PMI) della Commissione Europea e la confronta con definizioni affini adottate dalle organizzazioni internazionali. L’analisi approfondisce come la definizione dei termini di partecipazione
Andrea Bellucci, Gianluca Gucciardi
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Conceptual Design of a Modular Floating Multi-Purpose Island

Frontiers in Marine Science, 2021
The design of a modular floating multi-purpose island inherently involves interaction within a group with a large range of backgrounds such as engineering, architecture, sociology, climate modeling, and more.
Ingo Drummen, Gerrit Olbert
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Horizon 2020

, 2014
Horizon 2020 is the European Commission’s biggest research and innovation funding programme to date worth 80 billion over the next seven years (2014 to 2020). The programme is also open to private sector colleges. Marie O’ Neill discusses the rationale behind Horizon 2020, improvements on the FP7 programme as well as the research opportunities that the
openaire   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Building knowledge-based economy in the EU: methodological background and policy solutions [PDF]

International Economic Policy, 2018
The purpose of this paper is to highlight some major theoretical concepts, related to the notion of the knowledge-based economy, and to analyze EU policies, aimed at strengthening R&D potential and technologies commercialization of the EU member-states.
Lukasz Jablonski, Marek Jablonski, Oleksandr Fedirko   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source