Results 31 to 40 of about 52,856 (254)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
RUDN Journal of EconomicsThe study presents a study of Russian and foreign approaches to assessing the scientific and technological activities of scientific consortia. Scientific consortia are collaborations of scientific and educational organizations popular in Russia and in ...
Philipp D. Belov
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Horizon Europe: Open Science is the 'new' normal
, 2021 Starting from 2021, with the kickoff of the European Commission framework programme Horizon Europe, Open Science is expected to be the modus operandi in science. This presentation, given at the Åpen forskning: Delta i European Open Science Cloud organised on may 26, 2021 form the Research Council of Norway, is presenting the Open Science strategy of ...
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Energies, 2021 Cities generate about 85% of the EU’s GDP. As such, they are key players in shaping and providing technological and social innovations but also environmental impact.
Paola Clerici Maestosi +2 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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Gender Equality Plans and Inclusiveness in the European Research Area
Social InclusionGender equality is a key objective of the European Research Area. The arsenal of gender equality concepts has expanded considerably over the past decades—from gender mainstreaming in the 1990s to the current inclusion, diversity, and intersectionality ...
Mazlum Karataş +2 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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Forbes Tıp DergisiHorizon Europe is the European Union's key funding program for research and innovation. It tackles climate change, helps achieve the UN's Sustainable Development Goals, and boosts the EU's competitiveness and growth.
Fatma SUSAM
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