Results 41 to 50 of about 52,856 (254)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Daydream Continent: Europe as a Space-Time Horizon in Architectural History

Architectural Histories, 2018
This article defends an attention to past meanings of ‘Europe’ as a prospective idea, focusing on the circulation of architectural ideas between European states and settler territories in late colonialism. It proposes research that questions the relation
Tiago Castela
doaj   +1 more source

Energy Transition Metals: Future Demand and Low-Carbon Processing Technologies

Materials Proceedings, 2023
This paper discusses the importance of the energy transition metals Ni, Co and Li in building Europe’s clean technology value chains and meeting the 2050 climate-neutrality goal.
Konstantinos Komnitsas, Ilias Lazos, Toni Eerola   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Institutional leadership and regional contagion: Causal drivers of European research performance in the education sector

Management şi Marketing
Participation in the European Union’s Framework Programs such as Horizon Europe has become a strategic priority for higher and secondary education (HES) institutions, yet the underlying determinants of funding success remain difficult to disentangle due ...
Saftiuc Bogdan-Paul, Proșcanu Cosmin Adrian, Teodorescu Cosmin   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

New Horizons in the Europe of Knowledge

Journal of Contemporary European Research, 2015
This editorial introduces the notion of the Europe of Knowledge and places it in the European integration research agenda. We first describe what the concept means before suggesting how to approach the Europe of Knowledge as a new case for investigating European integration dynamics.
Chou, Meng-Hsuan, Ulnicane, Inga
openaire   +5 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Mapping leadership and communities in EU-funded research through network analysis [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Background Horizon 2020 and Horizon Europe are flagship programs of the European Union aimed at supporting research and innovation, fostering collaboration among companies, academic institutions, and research organizations. Comprehensive data on projects,
Alberto Soraci, Fabio Morea, Domenico De Stefano   +2 more
doaj   +1 more source