Results 41 to 50 of about 2,176,365 (198)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Artificial Intelligence-Driven Innovation in Cancer Surgery: A Systematic Review of Horizon Europe-Funded Projects

open access: yesForbes Tıp Dergisi
Horizon Europe is the European Union's key funding program for research and innovation. It tackles climate change, helps achieve the UN's Sustainable Development Goals, and boosts the EU's competitiveness and growth.
Fatma SUSAM
doaj   +1 more source

Sustainable Urban Areas for 2030 in a Post-COVID-19 Scenario: Focus on Innovative Research and Funding Frameworks to Boost Transition towards 100 Positive Energy Districts and 100 Climate-Neutral Cities

open access: yesEnergies, 2021
Cities generate about 85% of the EU’s GDP. As such, they are key players in shaping and providing technological and social innovations but also environmental impact.
Paola Clerici Maestosi   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Horizon Europe i ciència oberta [PDF]

open access: yes, 2022
Presentació dels requeriments en matèria de ciència oberta del programa Horizon Europe.Presention about the open science requirements of the Horizon Europe ...
Universitat Autònoma de Barcelona. Servei de Biblioteques
core   +1 more source

Gender Equality Plans and Inclusiveness in the European Research Area

open access: yesSocial Inclusion
Gender equality is a key objective of the European Research Area. The arsenal of gender equality concepts has expanded considerably over the past decades—from gender mainstreaming in the 1990s to the current inclusion, diversity, and intersectionality ...
Mazlum Karataş   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Daydream Continent: Europe as a Space-Time Horizon in Architectural History

open access: yesArchitectural Histories, 2018
This article defends an attention to past meanings of ‘Europe’ as a prospective idea, focusing on the circulation of architectural ideas between European states and settler territories in late colonialism. It proposes research that questions the relation
Tiago Castela
doaj   +1 more source

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