Results 61 to 70 of about 1,644,938 (307)

Horizontal Chemistry

The British Journal for the History of Science
In 1976 Raymond Williams commented, ‘Culture is one of the two or three most complicated words in the English language.’ Such implied difficulty has not prevented Bloomsbury Academic, since the 2000s, from publishing around forty series of their well-produced and generously illustrated Cultural Histories, with, according to their website, a further ...
Michelle, DiMeo, Andrew, Gregory, Frank A J L, James, Viviane, Quirke   +3 more
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Horizontal Mergers, Involuntary Unemployment, and Welfare [PDF]

Standard welfare analysis of horizontal mergers usually refers to two effects: the anticompetitive market power effect reduces welfare by enabling firms to charge prices above marginal costs, whereas the procompetitive efficiency ef-fect increases ...
Jürgen-Peter Kretschmer, Oliver Budzinski   +1 more
core   +2 more sources

Lexical Repetitions Functioning as Connectors in Verse Discourses

Stylistyka, 2006
The subject of this article are lexical repetitions functioning as connectors, or perfor[1]ming the organizational function, by serving as a means of connecting various poetic elements, giving compactness, expressiveness and multiplicity of meanings to ...
Milosav Ż. Ćarkić
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Using Leaf-Derived Materials to Stop Common Bed Bugs (Cimex lectularius L.) in Their Tracks

Insects
The common bed bug, Cimex lectularius L., is a pervasive pest of humans throughout the world. Insecticide resistance, cryptic habits, and proclivity for harborage on human belongings have contributed to its global status as a difficult pest to control ...
Patrick Liu, Jorge Bustamante, Kathleen Campbell, Andrew M. Sutherland, Dong-Hwan Choe, Catherine Loudon   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Comparaciones interpersonales, efectos redistributivos y equidad horizontal en el IRPF [PDF]

, 1995
Siguiendo los trabajos de Lambert y Ramos (1994) y Ruiz-Castillo (1995) en este trabajo se estiman los efectos redistributivos (ER) y cambios en el bienestar producidos por el impuesto sobre la renta en España. El impuesto se desdobla en la aplicación de
Vargas, Carmen
core   +1 more source

Numerical investigation of mixed convection in a square lid-driven cavity with influence of orientat

Journal of Thermal Engineering
Response surface methodology is employed to optimize the operating variables (i.e., Reynolds number (150 ≤ Re ≤ 2500), Grashof number (103 to 106) and Richardson number (0.01 ≤ Ri ≤ 12) with different orientations (horizontal and vertical) blocks with ...
T. Ravi Kumar REDDY
doaj   +1 more source