Results 111 to 120 of about 596,709 (329)

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Measuring degradation of transgenic DNA and screening for horizontal gene transfer from GMO-plant material during composting [PDF]

, 2004
The experiments show that composting of GM plant residues greatly increases the rate of degradation of transgenic DNA compared to the rate for plant residues left in the soil.
Magid, Jakob, Moeller, Jacob, Rasmussen, Lasse Dam   +2 more
core  

Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach [PDF]

, 2008
Background Poxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera.
Kirsten A Bratke, Aoife McLysaght
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Updated clusters of orthologous genes for Archaea: a complex ancestor of the Archaea and the byways of horizontal gene transfer

Biology Direct, 2012
Background Collections of Clusters of Orthologous Genes (COGs) provide indispensable tools for comparative genomic analysis, evolutionary reconstruction and functional annotation of new genomes.
Wolf Yuri I, Makarova Kira S, Yutin Natalya, Koonin Eugene V   +3 more
doaj   +1 more source

Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Colonization of the mammalian gut by trillions of commensal bacteria starts early in life and contributes to host health. However, colonization by pathogens can be the launching pad for infection.
N. Frazão, A. Sousa, M. Lässig, I. Gordo   +3 more
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

nec1, a Gene Conferring a Necrogenic Phenotype, Is Conserved in Plant-Pathogenic Streptomyces spp. and Linked to a Transposase Pseudogene

Molecular Plant-Microbe Interactions, 1998
We are investigating the genetic basis for, and evolution of, plant pathogenicity in Streptomyces spp. The plant-pathogenic species S. scabies, S. acidiscabies, and S.
Raghida A. Bukhalid, Soo Young Chung, Rosemary Loria   +2 more
doaj   +1 more source

Widespread impact of horizontal gene transfer on plant colonization of land [PDF]

, 2012
In complex multicellular eukaryotes such as animals and plants, horizontal gene transfer is commonly considered rare with very limited evolutionary significance.
A Schaller, AA Wiszniewski, AK Werner, AO Richardson, B Wang, B Zhu, C Esser, C Zhao, D Cove, D Pisani, DC Price, EG Danchin, G Emiliani, G Noctor, G Ricard, G Sun, G Sun, H Ochman, H Philippe, H Tanaka, HA Schmidt, J Huang, J Huang, J Huang, JD Hackett, JO Andersson, JO Andersson, JO Andersson, JO Andersson, JP Gogarten, L Belbahri, L Klasson, LE Graham, LW Neuteboom, M Koulintchenko, M Syvanen, MC Brundrett, MJ Sanderson, NA Moran, PA Christin, PJ Keeling, R Alcazar, R Bock, S Guindon, S Yoshida, SD Copley, T Davidsen, T Flores, T Kusano, T Ni, TA Richards, TM Keane, U Bergthorsson, VV Goremykin, W Martin, Y Cheng   +55 more
core   +1 more source

Horizontal gene transfer contributes to virulence and antibiotic resistance of Vibrio harveyi 345 based on complete genome sequence analysis

BMC Genomics, 2019
Horizontal gene transfer (HGT), which is affected by environmental pollution and climate change, promotes genetic communication, changing bacterial pathogenicity and drug resistance.
Yiqin Deng, Haidong Xu, Youlu Su, Songlin Liu, Li-wen Xu, Zhixun Guo, Jinjun Wu, Changhong Cheng, Juan Feng   +8 more
semanticscholar   +1 more source