Results 31 to 40 of about 203,484 (257)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Experimental Study on Fluid Producing Profile Monitoring by Distributed Optical Fiber in Casing of Horizontal Wells

Shiyou jixie, 2023
The problem of water breakthrough in the production process of waterflooding horizontal wells in low permeability oilfield is increasingly outstanding,and water detection test is an important prerequisite for achieving efficient management of water ...
Li Dajian, Liu Guangsheng, Du Xiangqian, Yang Wenfei, Zhang Honggang   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of Horizontal Displacement from Horizontal Control Network Adjustment Result Using Observation Model and Time-Variant Methods (Case Study : Horizontal Control Network of Borobudur Temple, Epoch 2002, 2003 and 2012)

Journal of Geospatial Information Science and Engineering, 2018
Borobudur Temple is the biggest Buddhist Temple in the world protected by UNESCO. Therefore the periodical maintenance of Borobudur temple become important, deformation study through displacement analysis can be applied for it, by conducting Geodetic ...
Een Lujainatul Isnaini, Dwi Lestari
doaj   +1 more source

A deep learning approach for signal identification in the fluid injection process during hydraulic fracturing using distributed acoustic sensing data

Frontiers in Earth Science, 2022
Full-cycle and real-time monitoring of the wellbore flow during hydraulic fracturing is challenging in unconventional oil and gas development. In the past few years, distributed acoustic sensing (DAS) provides opportunities to measure the acoustic energy
Yikang Zheng, Yikang Zheng, Yibo Wang, Yibo Wang, Xing Liang, Qingfeng Xue, Qingfeng Xue, Enmao Liang, Shaojiang Wu, Shaojiang Wu, Shujie An, Yi Yao, Yi Yao, Chen Liu, Jue Mei   +14 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Support of large taxpayers foreign experience and its actuality for Ukraine

Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2016
The article deals with the features of foreign experience of support of large taxpayers considering its actuality for Ukraine in terms of harmonization of relations between fiscal authorities and taxpayers.
O.S. Vatamaniuk
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Fusing BDS and Dihedral Corner Reflectors for High-Precision 3D Deformation Measurement: A Case Study in the Jinsha River Reservoir Area

Remote Sensing
In mountainous canyon regions, BeiDou Navigation Satellite System (BDS)/Global Navigation Satellite System (GNSS) receivers are susceptible to multireflection and tropospheric factors, which frequently reduce the accuracy in monitoring vertical ...
Zhiyong Qi, Yanpian Mao, Zhengyang Tang, Tao Li, Rongxin Fang, You Mou, Xuhuang Du, Zongyi Peng   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source