Results 41 to 50 of about 881,069 (299)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Analysis of BDS/GPS Deformation Monitoring for the Lake Sarez Dam

Remote Sensing, 2023
The Sarez Dam, currently recognized as the world’s highest natural dam, holds immense economic significance, necessitating the reliable monitoring and early detection of potential deformations.
Junqiang Han, Rui Tu, Xiaochun Lu, Lihong Fan, Wenquan Zhuang, Weisheng Wang, Feng Zhao, Bayin Dalai, Gulayozov Majid Shonazarovich, Mustafo Safarov   +9 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Assessing Potential Shale Gas Impacts on Groundwater Resources: Recommendations for Groundwater Monitoring and Definition of Baseline Conditions [PDF]

, 2018
Exploitation of shale gas by hydraulic fracturing (fracking) is highly controversial and concerns have been raised regarding induced risks from this extraction technique.
Banks, David, Burnside, Neil, Gunning, Andrew, Isherwood, Catherine, Kelly, Thomas, Montcoudiol, Nelly   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Support of large taxpayers foreign experience and its actuality for Ukraine

Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2016
The article deals with the features of foreign experience of support of large taxpayers considering its actuality for Ukraine in terms of harmonization of relations between fiscal authorities and taxpayers.
O.S. Vatamaniuk
doaj  

Fusing BDS and Dihedral Corner Reflectors for High-Precision 3D Deformation Measurement: A Case Study in the Jinsha River Reservoir Area

Remote Sensing
In mountainous canyon regions, BeiDou Navigation Satellite System (BDS)/Global Navigation Satellite System (GNSS) receivers are susceptible to multireflection and tropospheric factors, which frequently reduce the accuracy in monitoring vertical ...
Zhiyong Qi, Yanpian Mao, Zhengyang Tang, Tao Li, Rongxin Fang, You Mou, Xuhuang Du, Zongyi Peng   +7 more
doaj   +1 more source

THE TAX CONTROL AS A COMPONENT OF TAX ADMINISTRATION

Aktualʹnì Problemi Rozvitku Ekonomìki Regìonu, 2017
In the article the features of tax control in the system of taxes administration were investigated. The basic approaches to the determination of tax control were defined.
Olga Zhuk
doaj   +1 more source

EU and OECD benchmarking and peer review compared [PDF]

, 2009
Benchmarking and peer review are essential elements of the so-called EU open method of coordination (OMC) which has been contested in the literature for lack of effectiveness.
Groenendijk, Nico
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source