Results 151 to 160 of about 561,014 (300)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Role of oral gonadotropin-releasing hormone antagonists in the management of uterine adenomyosis: a narrative review. [PDF]

Reprod Fertil
Donnez J, Donnez O, Taylor HS, Petraglia F, Horne AW, Becker CM, Renner SP, Rius M, Bestel E, Stratopoulou CA, Dolmans MM.   +10 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Bone Targeted Parathyroid Hormone Antagonists for Prevention of Breast Cancer Bone Metastases. [PDF]

Cancers (Basel)
Anbalagan M, Ponnapakkam T, Zou B, Williams J, Saeg F, Burow ME, Gensure RC, Rowan BG.   +7 more
europepmc   +1 more source

Hormone Antagonist [PDF]

, 2020
openaire   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

Gonadotrophin-releasing hormone antagonists: application in ovary-stimulating and sex-steroid dependent disorders

, 2000
The hypothalamic gonadotrophin-releasing hormone (GnRH) stimulates synthesis and secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the gonadotrophic cells of the pituitary. The mechanisms of action of GnRH antagonists and of
de Jong, D., Macklon, N.S., Fauser, B.C., Laven, J.S.   +3 more
core   +1 more source

Oral Gonadotropin-Releasing Hormone Antagonists in the Treatment of Endometriosis: Advances in Research. [PDF]

J Clin Med Res
Wang JY, Zhang Y, Ding J.
europepmc   +1 more source

Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. [PDF]

Cochrane Database Syst Rev, 2016
Al-Inany HG, Youssef MA, Ayeleke RO, Brown J, Lam WS, Broekmans FJ.   +5 more
europepmc   +1 more source