Results 31 to 40 of about 561,014 (300)

HORMONE THERAPY WITH USAGE OF AGONISTS AND ANTAGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE IN PATIENTS WITH PROSTATE CANCER

Исследования и практика в медицине, 2015
Prostate cancer (PC) is one of the most actual problems of modern oncourology. Hormone therapy (HT) using medical castration is the main method of treatment of patients with metastatic PC.
K. M. Nyushko, A. A. Krasheninnikov, M. P. Golovaschenko, A. D. Kaprin   +3 more
doaj   +1 more source

Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor [PDF]

, 2008
Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
core   +1 more source

Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells [PDF]

, 1994
A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang, Angerer, S. von, Angerer, E. von, Seidl, E., Mannschreck, A.   +4 more
core   +1 more source

GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy

Pharmaceuticals
Overexpression of the gonadotropin-releasing hormone receptor (GnRH-R) plays a vital role in the advancement of reproductive malignancies such as ovarian, endometrial, and prostate cancer.
Shikha Patel, Bhagawati Saxena, Priti Mehta, Sarfaraz K. Niazi   +3 more
doaj   +1 more source

P53 in lung vascular barrier dysfunction

Vascular Biology, 2020
Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose of the present editorial is to emphasize on recent advances in the corresponding field, as it ...
Nektarios Barabutis
doaj   +1 more source

In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

iScience, 2021
Summary: Chemicals acting as thyroid hormone disruptors (THDs) are of a particular concern for public health, considering the importance of this hormone in neurodevelopment and metabolic processes. They might either alter the circulating level of thyroid
Yanis Zekri, Laure Dall Agnol, Frédéric Flamant, Romain Guyot   +3 more
doaj   +1 more source

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A   +12 more
core   +1 more source

Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy [PDF]

, 2004
Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported ...
Briggs, TW, Pringle, J, Lee, RS, Higgs, D, Haddo, O   +4 more
core  

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Luteinizing hormone-releasing hormone receptor agonists and antagonists in prostate cancer: effects on long-term survival and combined therapy with next-generation hormonal agents

Cancer Biology & Medicine
Prostate cancer is a leading cause of cancer-related death in men worldwide. Luteinizing hormone-releasing hormone receptor (LHRH-R) agonists and antagonists are known to achieve castration-level testosterone suppression; however, long-term data ...
Jinge Zhao, Junru Chen, Guangxi Sun, Pengfei Shen, Hao Zeng   +4 more
doaj   +1 more source