Results 161 to 170 of about 118,032 (300)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

European Code Against Cancer, 5th edition - hormone replacement therapy, other common medical therapies and cancer. [PDF]

Mol Oncol
Thorat MA, Arbyn M, Baldwin D, Castells X, Hofvind S, Ivanus U, Senore C, Toes-Zoutendijk E, van der Aalst C, Canelo-Aybar C, Fernández-Sáenz FK, Feliu A, Zeeb H, Carvalho AL, D'Souza E, Ritchie D, Espina C, Lansdorp-Vogelaar I, DeCensi A.   +18 more
europepmc   +1 more source

Hormone replacement therapy [PDF]

BMJ, 1997
G. Venning, S Lange
openaire   +1 more source

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

, 2014
İkbal Kaygusuz, Serap Simavlı, Ayla Eser, İlknur İnegöl Gümüş, Selcen Yüksel, Zehra Candan İltemir Duvan, Hasan Kafalı   +6 more
openalex   +1 more source

Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones? [PDF]

, 2012
Manthos G. Giannoulis, Finbarr C. Martin, K. Sreekumaran Nair, A. Margot Umpleby, Peter H. Sönksen   +4 more
openalex   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Changes in Fertility and Hormone Replacement Therapy in Kidney Disease [PDF]

, 2013
Jean L. Holley, Rebecca J. Schmidt
openalex   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

A case of hypopituitarism with pancytopenia cured by corticosteroid and thyroid hormone replacement therapy. [PDF]

Endocrinol Diabetes Metab Case Rep
Mladenovic V, Zaric RZ, Sretenovic S, Bubanja D, Ivosevic Z, Igrutinovic N, Nesic J, Djurdjevic P.   +7 more
europepmc   +1 more source

All women with multiple sclerosis should start hormone replacement therapy at menopause unless contraindicated: Commentary [PDF]

Kate Petheram, Ruth Dobson
openalex   +1 more source