Results 251 to 260 of about 258,704 (366)

Contemporary Perspectives on Chronic Renal Disorders

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok   +5 more
wiley   +1 more source

Effects of information framing on the intentions of family physicians to prescribe long-term hormone replacement therapy

open access: green, 1999
Jasminka Nikolajevic‐Sarunac   +3 more
openalex   +2 more sources

Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay

open access: yesChemistry – A European Journal, EarlyView.
We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková   +11 more
wiley   +1 more source

An Efficient Thiol‐ene Mediated Protocol for Thiolated Peptide Synthesis and On‐Resin Diversification

open access: yesChemistry – A European Journal, EarlyView.
Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa   +5 more
wiley   +1 more source

Effect of hormone replacement therapy on growth hormone stimulation in women with premature ovarian failure

open access: bronze, 1997
Beda Hartmann   +4 more
openalex   +1 more source

Further Structure‐Activity Relationship of G Protein‐Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

open access: yesChemMedChem, EarlyView.
Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid   +8 more
wiley   +1 more source

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