Results 261 to 270 of about 258,704 (366)

Novel 4,5‐Dihydrothiazole‐phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

open access: yesChemMedChem, Accepted Article.
We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi   +18 more
wiley   +1 more source

Exploring hormone replacement therapy dynamics among menopausal women in Kuala Lumpur - a community based survey. [PDF]

open access: yesBMC Womens Health
Gan MH   +5 more
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

open access: yesChemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui   +2 more
wiley   +1 more source

Advancing FIRES Treatment: The Potential of Intrathecal Dexamethasone

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a rare, devastating epilepsy syndrome characterized by refractory status epilepticus following a febrile illness. Patient Description We describe a 12‐year‐old girl with FIRES who exhibited a remarkable clinical and electrographic response to intrathecal dexamethasone (IT‐DEX ...
Carol Park   +10 more
wiley   +1 more source

Evaluation of Potential Effects of CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Fruquintinib in Healthy Subjects

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez   +5 more
wiley   +1 more source

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