Treatment of symptoms of the menopause: an endocrine society clinical practice guideline [PDF]
Objective: The objective of this document is to generate a practice guideline for the management and treatment of symptoms of the menopause. Participants: The Treatment of Symptoms of the Menopause Task Force included six experts, a methodologist, and
Davis, Susan R.+6 more
core +1 more source
3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht+5 more
wiley +1 more source
Obesity, type 2 diabetes and hormone replacement therapy vs. colorectal tumors in the elderly
Aims. A prophylaxis program for the early detection of colorectal cancer carried out by our department since the year 2000 has been extended to include people aged 65 and older. The subjects were asked additional questions regarding their dietary habits
Małgorzata Szamocka+4 more
doaj +3 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan+4 more
wiley +1 more source
Metabolic, inflammatory and haemostatic effects of a low-dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk? [PDF]
BACKGROUND Conventional hormone replacement therapy (HRT) containing conjugated equine oestrogen (CEE) and medroxyprogesterone acetate (MPA) increases triglyceride, C- reactive protein (CRP) and coagulation Factor VII concentrations, potentially ...
Alan J. Jaap+46 more
core +1 more source
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray+2 more
wiley +1 more source
HORMONE REPLACEMENT THERAPY AND CANCER
Background. Sex steroids are not known to damage DNA directly. They can stimulate or inhibit cell proliferation, and thus can modulate tumor developmental progression.Results.
Marjetka Uršič Vrščaj
doaj
Hormone replacement therapy and women's health: umbrella review of interventional and observational studies. [PDF]
This review aims to undertake an umbrella review of systematic reviews and meta-analyses of observational and interventional studies investigating the role of hormone replacement therapy in the primary and secondary prevention of multiple health and ...
Critchley, Hilary+6 more
core +1 more source
Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Barnett, A. H.+5 more
core +1 more source
Progestin drugs are loaded into a mesoporous silicon dioxide host by melt‐infiltration. Drugs that decompose at or close to their melting point can be loaded by the addition of cholesterol, which acts as a melting point suppressor. High mass loading of the drug is achieved, and dissolution of the composite is controlled by the nanoscale properties of ...
Geoffrey Hollett+13 more
wiley +1 more source