Results 41 to 50 of about 223,656 (296)

Decision aids for people facing health treatment or screening decisions (Review) [PDF]

, 2009
Background Decision aids prepare people to participate in ’close call’ decisions that involve weighing benefits, harms, and scientific uncertainty. Objectives To conduct a systematic review of randomised controlled trials (RCTs) evaluating the efficacy ...
Adab, Armstrong, Auvinen, Auvinen, Barry, Bastian, Bekker, Bekker, Bekker, Bernstein, Briss, Brown, Brundage, Chadwick, Charles, Chewning, Clancy, Colella, Coulter, Crang-Svalenius, Davison, Davison, Deber, Deber, Degner, Deschamps, Deyo, Dodin, Dolan, Dunn, Elwyn, Emmett, Ende, Entwistle, Flood, Frosch, Frosch, Gafni, Gattellari, Gattellari, Godlee, Goel, Graham, Gravel, Green, Green, Green, Green, Greenfield, Gruppen, Gruppen, Hays, Healton, Herrera, Hewison, Hickish, Hochlehnert, Holloway, Holmes-Rovner, Hunt, Hunter, Hunter, Jadad, Johnson, Jorm, Kennedy, LaCroix, Lalonde, Laupacis, Lazcano Ponce, Legare, Lerman, Leung, Lewis, Llewellyn-Thomas, Maisels, Makoul, Man-Son-Hing, Manns, Markham, Martin, Maslin, Maslin, Mazur, McAlister, McBride, McGinley, McInerney-Leo, Michie, Miller, Molenaar, Molenaar, Montgomery, Morgan, Mulley, Mulley, Murray, Murray, Myers, Myers, Nagle, Newton, O'Cathain, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, O'Connor, Oakley, Partin, Pearson, Peele, Phelan, Phillips, Pignone, Proctor, Radloff, Ratliff, Rimer, Rimer, Roland, Roosmalen, Roosmalen, Rostom, Rothert, Rothert, Rovner, Ruland, Ryser, Schapira, Schwartz, Sepucha, Sheridan, Shorten, Sorenson, Spielberger, Stacey, Steiner, Stewart, Street, Street, Tabak, Thomson, Thornton, Valdez, Volk, Volk, Vuorma, Vuorma, Wagner, Wallston, Wang, Whelan, Whelan, Whitney, Willemsen, Wolf, Wolf, Wolf, Wong, Wroe, Zapka   +170 more
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Long-term hormone replacement therapy [PDF]

, 2000
Reproduced with permission from Australian Prescriber The document attached has been archived with permission from the publisher/copyright holderAlastair H ...
MacLennan, A.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Hormone replacement therapy in menopause [PDF]

, 2014
Although estrogen has been clinically available for more than six decades, women have been confused by different opinions regarding the risks and benefits of menopausal hormone therapy (HT), estrogen therapy (ET), and estrogen-progestin therapy (EPT ...
Pardini, Dolores
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The effects of hormone replacement therapy on mammographic density among postmenopausal women in Hospital Raja Perempuan Zainab Ii, Kota Bharu, Kelantan. [PDF]

, 2011
Introduction Hormone replacement therapy (HRT) is commonly prescribed to postmenopausal women to improve their postmenopausal symptoms. Postmenopausal hormone use is associated with increase in mammographic density and increased incidence of breast pain.
Kamaravel, Shanti
core  

Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role? [PDF]

, 2018
Secondary adrenal insufficiency (SAI) is a potentially life-threatening endocrine disorder due to an impairment of corticotropin (ACTH) secretion from any process affecting the hypothalamus or pituitary gland.
Gianfrilli, Daniele, Graziadio, Chiara, Hasenmajer, Valeria, Isidori, Andrea M., Sbardella, Emilia, Venneri, Mary A.   +5 more
core   +2 more sources

Postmenopausal hormone replacement therapy

Ceylon Medical Journal, 2011
We need to clarify our practice guidelines and open a dialogue with our patients DOI: http://dx.doi.org/10.4038/cmj.v49i3.3242 Ceylon Medical Journal 2004; 49: 73 ...
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source