Results 61 to 70 of about 125,967 (307)

The Controversial History of Hormone Replacement Therapy

Medicina, 2019
The history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the
Angelo Cagnacci, Martina Venier
doaj   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Cardiovascular risk in hormone replacement therapy

Bleeding, Thrombosis and Vascular Biology
Hormone replacement therapy (HRT) effectively alleviates vasomotor symptoms related to menopause, but it can also raise the risk of cardiovascular disease. Several factors influence the likelihood of developing coronary artery disease or ischemic stroke,
Doris Barcellona
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

A reassessment of the cost-effectiveness of hormone replacement therapy in Sweden – results based on the Women’s Health Initiative randomised controlled trial [PDF]

The cost-effectiveness of hormone replacement therapy (HRT) based on a societal perspective is reassessed based on new medical evidence found in the Women’s Health Initiative (WHI).
Jönsson, Bengt, Borgström, Fredrik, Zethraeus, Niklas, Kanis, John   +3 more
core  

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Hormone Replacement Therapy after Unilateral Adrenalectomy

Journal of Education, Health and Sport
Unilateral adrenalectomy is widely performed for the treatment of both hormonally active and inactive adrenal tumors; however, the need for postoperative hormone replacement therapy (HRT) remains controversial. This study aimed to evaluate the necessity,
R. Parfentiev, Yu. Kryzhanovskyi, V. Sliepov, V. Vododyuk, N. Parfentieva   +4 more
doaj   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Ductal carcinoma In-Situ in turner syndrome patient undergoing hormone replacement therapy: A case report

, 2016
Turner’s syndrome is a rare congenital disease which affects about 1 in every 2500-3000 live-born females. This happens due to chromosomal abnormalities in a phenotypic female, causing increased gonadotropin concentrations and low concentrations of ...
Matemavi, Praise; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York, Maizlin, Ilan; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York, Bawa, Rashmi; Department of Surgery, Pine Health Services, Maine, Sung, Kap-Jae; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York   +3 more
core   +1 more source

Taking hormone replacement therapy

BMJ, 2003
Women and health professionals should make the decision jointly and review it periodically In the United Kingdom women at midlife are facing the decision whether to take hormone replacement therapy or not. The backdrop to this includes widespread discussion in the media of hormone replacement therapy, high levels of lay awareness, a medical ...
openaire   +3 more sources