Results 161 to 170 of about 474,365 (309)

Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies

, 2014
Peifu Wang, Jilai Li, Shi Qiu, Honfeng Wen, Jichen DuDepartment of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, People’s Republic of ChinaBackground and purpose: Published data on the relationship of ...
Wen H, Wang P, Li J, Qiu S, Du J
core  

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Trends in Government-Subsidised Menopausal Hormone Therapy Dispensing in Australia Between 2014 and 2023. [PDF]

Aust N Z J Obstet Gynaecol
Risni HW, Wei L, Hickey M, Grzeskowiak L, Ilomäki J, Brauer R.   +5 more
europepmc   +1 more source

Hormone Therapy in Malignancies

Cleveland Clinic Journal of Medicine, 1951
openaire   +2 more sources

Growth hormone deficiency: strategies and indications to continue growth hormone therapy in transition from adolescence to adult life

, 2003
The most common practice in children with growth hormone (GH) deficiency is to discontinue GH treatment in adolescence after attainment of final height.
Johannsson, Gudmundur,, Leong, Gary M
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Growth hormone therapy in children with temple syndrome: the first retrospective study in China. [PDF]

BMC Pediatr
Wang X, Chen R, Su Z, Fan X, Shen L, Song F, Liu Z, Gong C, Cao B.   +8 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Thyroid hormone therapy in a population cohort over two decades indicates persistent overtreatment. [PDF]

Eur Thyroid J
Zwanziger D, Kowall B, Klose JM, Schmidt B, Stang A, Führer D.   +5 more
europepmc   +1 more source