Results 101 to 110 of about 310,142 (293)

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis

open access: yesAdvanced Science, EarlyView.
Meiosis is a specialized form of cell division that has different regulation and mechanisms with mitosis in numerous aspects. Particularly, meiosis I is unique and occurs only in germ cells to separate homologous chromosomes. Thus, determining how this unusual chromosome segregation behavior is established is central to understanding germ cell ...
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
wiley   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan   +10 more
wiley   +1 more source

Electrochemical Doping for Absorption and Conductivity Tuning of P(NDI2OD‐T2) Films

open access: yesAdvanced Electronic Materials, EarlyView.
Electrochemical doping of P(NDI2OD‐T2) films allows for tuning the degree of doping both in liquid electrolytes as well as in the solid state. The nature of the doped species is elucidated by UV–vis spectroscopy and accompanying DFT calculations. Correlations between maximum conductivities and the presence of mixed valence states, (specifically neutral/
David Neusser   +8 more
wiley   +1 more source

The Influence of Magnetothermal Stimulation on Viability of Cells in 2D Cultures and 3D Magnetic Collagen Gels

open access: yesAdvanced Electronic Materials, EarlyView.
This manuscript presents a novel framework for evaluating cell viability in the emerging field of magnetothermal stimulation, applied to 2D and 3D cell cultures. It introduces a tunable, stimuli‐responsive magnetic collagen gel designed to support controlled thermal stimulation.
Shahar Shalom   +6 more
wiley   +1 more source

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

open access: yesAdvanced Intelligent Systems, EarlyView.
The integration of sensing elements in bioengineered actuators is key to obtain real‐time information about their performance and further control/automation. By coupling flexible organic field‐effect transistor to a skeletal muscle actuator we demonstrate the feasibility to record in real‐time its contractile behavior when stimulated by electrical ...
Stefano Lai   +5 more
wiley   +1 more source

Structural Insight Into a Human H Ferritin@Gold‐Monocarbene Adduct: Aurophilicity Revealed in a Biological Context

open access: yesAngewandte Chemie, EarlyView.
Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini   +9 more
wiley   +2 more sources

Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots

open access: yesAdvanced Intelligent Systems, EarlyView.
Skeletal muscle tissue‐based bioactuators move in response to externally applied electrical stimuli in open‐loop control, which lacks knowledge of the actuator's state. Herein, a soft and fiber‐shaped piezoresistive mechanosensor that integrates with the soft tissue and operates in the cell culture environment is used to create the first proprioceptive
Miriam Filippi   +8 more
wiley   +1 more source

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue

open access: yesAdvanced Intelligent Systems, EarlyView.
A scalable, monolithic biohybrid flexure mechanism is presented, integrating engineered skeletal muscle tissue with a soft, biocompatible, hollow silicone cylinder featuring dual pillars. Muscle contraction induces bending motion upon electrical stimulation, with performance governed by the structure's flexural rigidity.
Andrea Bartolucci   +13 more
wiley   +1 more source

DuckyDog: An Erect Amphibious Robot with Variable‐Stiffness Legs and Passive Fins

open access: yesAdvanced Intelligent Systems, EarlyView.
DuckyDog, a quadruped amphibious robot using erect posture, is proposed with dog‐inspired tendon‐driven compliant legs for walking and paddling, a duck‐inspired body for buoyancy, and passive fins to increase propulsion. It achieves maximum speeds of 0.4 body lengths per second on land and 0.3 on water, demonstrating the ability to navigate in complex ...
Yilin Wang   +3 more
wiley   +1 more source

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