Results 71 to 80 of about 2,526,971 (303)
, 1974 9 p. transcript of an interview with Fred Horse conducted by Richard Lightning, probably in 1974. Tape number IH-186A, transcript disc 27A.Gives the history of the Frog Lake Reserve and the taking of and interpretation of Treaty #6 ...
Horse, Fred, Lightning, Richard
core +1 more source
Advanced Science, EarlyView.Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma +12 more
wiley +1 more source
Advanced Science, EarlyView.Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen +4 more
wiley +1 more source
Advanced Science, EarlyView.The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng +6 more
wiley +1 more source
Horse riding in protected areas: a critical review and implications for research and management [PDF]
, 2008 Horse riding is a popular, high-impact recreational activity that occurs worldwide. The United States and Australia have a long history of recreational horse riding in protected areas and controversy accompanies this activity in both countries.
Newsome, D., Smith, A., Moore, S.A.
core
Advanced Science, EarlyView.Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert +10 more
wiley +1 more source
, 1975 7 p. transcript of an interview with Fred Horse conducted by Richard Lightning on March 14, 1975. Tape number IH-186B, transcript disc 25.Talks of Indian attitudes to treaty promises, reserves, missionaries ...
Horse, Fred, Lightning, Richard
core +1 more source
Advanced Science, EarlyView.Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang +11 more
wiley +1 more source
Regulatory pathway analysis of coat color genes in Mongolian horses
Hereditas, 2017 Background Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats ...
Bei Li +6 more
doaj +1 more source
Advanced Science, EarlyView.Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong +7 more
wiley +1 more source