Results 171 to 180 of about 882,157 (403)

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

open access: yesAdvanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu   +7 more
wiley   +1 more source

From Waste to Wealth: A Review of Eutectic Molten Salt Method for Direct Regeneration of Spent Lithium‐Ion Battery

open access: yesAdvanced Science, EarlyView.
The main process of the eutectic molten salt method and the direct regeneration of Spent lithium (Li)‐ion batteries by the eutectic molten salt method have brought structural, performance, environmental, and economic benefits. Abstract The rapid growth of electric vehicles (EVs) has significantly increased the demand for lithium (Li)‐ion batteries ...
Junyi Wang   +3 more
wiley   +1 more source

Show Quality Quarter Horse Auctions: Price Determinants and Buy-Back Practices [PDF]

open access: yes
This study estimates the price determinants of show quality quarter horses sold at auction. Several characteristics including genetic and physical traits, quality of pedigree, and performance record of the horse, as well as the horse's offspring, were ...
Dhuyvetter, Kevin C.   +4 more
core   +1 more source

Label‐Free Single‐Molecule Immunoassay

open access: yesAdvanced Science, EarlyView.
Label‐free single‐molecule immunoassay (LFSMiA) enables ultra‐sensitive and wide dynamic range protein detection in whole blood samples. LFSMiA features real‐time single‐molecule imaging by plasmonic scattering microscopy, background reduction by a 2‐step sandwich assay, minimizing matrix effect by dynamic tracking of single binding events, and ...
Xiaoyan Zhou   +11 more
wiley   +1 more source

Ancient genomes revisit the ancestry of domestic and Przewalski’s horses

open access: yesScience, 2018
Charleen Gaunitz   +46 more
semanticscholar   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

Development, refinement, and validation of an equine musculoskeletal pain scale

open access: yesFrontiers in Pain Research
Musculoskeletal disease is a common cause of chronic pain that is often overlooked and inadequately treated, impacting the quality of life of humans and horses alike. Lameness due to musculoskeletal pain is prevalent in horses, but the perception of pain
Ulrike Auer   +8 more
doaj   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

open access: yesAdvanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra   +9 more
wiley   +1 more source

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