Results 171 to 180 of about 893,278 (399)

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Properdin, transcortin and HGFAC are novel plasma biomarkers in canine chronic inflammatory enteropathies from active disease to remission

Scientific Reports
Canine chronic inflammatory enteropathies (CCIE) is a group of intestinal inflammatory conditions causing chronic or relapsing gastrointestinal symptoms.
Pavlos G. Doulidis, Carolina Frizzo Ramos, Alexandro Rodriguez-Rojas, Franziska Roth-Walter, Iwan A. Burgener   +4 more
doaj   +1 more source

Comparison of thoracic computed tomography and surgical reports in dogs and cats

Frontiers in Veterinary Science
IntroductionThis retrospective study compared computed tomography (CT) and surgical reports in 41 dogs and 23 cats undergoing thoracic surgery (50 thoracotomies, 14 thoracoscopies).ObjectivesThe objective of this study was to evaluate the agreement ...
Maja Brložnik, Martin Immler, Maria Laura Prüllage, Olivia Mariel Grünzweil, Manolis Lyrakis, Eberhard Ludewig, Sibylle Maria Kneissl   +6 more
doaj   +1 more source

Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism

Advanced Science, EarlyView.
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding, Yuhuan Jia, Lin Liu, Wen Wang, Danxia Zhou, Zheng Zhou, Likun Yang, Xinyi Chen, Di Chen, Yan Mao, Liwei Xiao, Cai‐Zhi Liu, Zhen‐Yu Du, Yujing Yin, Qiqi Guo, Zongchao Sun, Kai Ge, Tingting Fu, Hai‐Long Piao, Zhenji Gan   +19 more
wiley   +1 more source

A validation study to analyze the reliability of center of pressure data in static posturography in dogs

Frontiers in Veterinary Science
IntroductionCenter of pressure (COP) parameters are frequently assessed to analyze movement disorders in humans and animals. Methodological discrepancies are a major concern when evaluating conflicting study results.
Masoud Aghapour, Nadja Affenzeller, Nadja Affenzeller, Christiane Lutonsky, Christian Peham, Alexander Tichy, Barbara Bockstahler   +6 more
doaj   +1 more source

A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS [PDF]

, 1931
Elliott R. Weyer, William H. Park, E Banzhaf   +2 more
openalex   +1 more source

RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin

Advanced Science, EarlyView.
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain, Yao Gao, Sharmeen Islam, Li‐Wei Chen, Xinrui Li, Zhongyun Kou, Nathan C Law, Jeanene Marie de Avila, Mei‐Jun Zhu, Min Du   +9 more
wiley   +1 more source

Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations [PDF]

, 2019
This study aimed to evaluate the relationship between the serum concentrations of lidocaine/ monoethylglycinexylidide (MEGX) and their effects on several systems in horses.
Amory, H, Busoni, V, Croubels, Siska, Detilleux, J, Lopez Arevalo, DM, Maes, An, Salciccia, A, Sandersen, C   +7 more
core   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Ancient genomes revisit the ancestry of domestic and Przewalski’s horses

Science, 2018
Charleen Gaunitz, A. Fages, Kristian Hanghøj, A. Albrechtsen, Naveed Khan, Mikkel Schubert, Andaine Seguin-Orlando, Ivy J Owens, S. Felkel, Olivier Bignon-Lau, Peter de Barros Damgaard, Alissa Mittnik, A. Mohaseb, H. Davoudi, S. Alquraishi, A. Alfarhan, K. Al-Rasheid, É. Crubézy, N. Benecke, Sandra L. Olsen, Dorcas Brown, D. Anthony, Ken Massy, V. Pitulko, A. Kasparov, G. Brem, M. Hofreiter, G. Mukhtarova, N. Baimukhanov, L. Lōugas, V. Onar, P. Stockhammer, J. Krause, B. Boldgiv, Sainbileg Undrakhbold, D. Erdenebaatar, S. Lepetz, M. Mashkour, A. Ludwig, B. Wallner, Victor Merz, Ilja Merz, Viktor Zaibert, E. Willerslev, P. Librado, A. Outram, L. Orlando   +46 more
semanticscholar   +1 more source