Results 41 to 50 of about 31,395 (217)

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot   +8 more
wiley   +1 more source

Understanding the benefits and limitations of mixing virtual and face-to-face consultations to outpatient palliative care services; a mixed-methods study

BMC Palliative Care
Background The Covid-19 pandemic led to a rapid increase in the use of virtual consultations across healthcare. Post-pandemic, this use is expected to continue alongside the resumption of traditional face-to-face clinics.
Caradoc Morris, David Waterman, Lesley Anne Henson   +2 more
doaj   +1 more source

Medication Use During Breastfeeding—An Understudied Population: A Five‐Year Experience in the Pharmacovigilance Center of Lyon

Clinical Pharmacology &Therapeutics, EarlyView.
Medication use during breastfeeding is common, yet data on drug transfer into breast milk and infant exposure remain limited. This study describes real‐world requests concerning medication compatibility with breastfeeding managed by the Lyon pharmacovigilance center over five years.
Blandine Bertin, Aurore Gouraud, Anthony Facile, Fanny Ledys, Sabrina Pierre, Véronique Pizzoglio, Thierry Vial, Marine Auffret, Marina Atzenhoffer   +8 more
wiley   +1 more source

Caregiver experience of specialist hospice palliative care in rural communities: A qualitative study exploring rural culture, hospice nurse characteristics, roles, and carer strategic ideas

Palliative Care and Social Practice
Background: Barriers, facilitators, and inequity of access to rural palliative care have been explored from caregiver and healthcare worker perspectives. However, caregiver insights into specialist (secondary) hospice palliative care are sparse.
Rowan Daniel Beaumont Bell, Caren Amanda Barnett, Matthew Joseph Wilson, Philippa Marie Twigg   +3 more
doaj   +1 more source

Impact of a hospice rapid response service on preferred place of death, and costs [PDF]

, 2015
Background: Many people with a terminal illness would prefer to die at home. A new palliative rapid response service (RRS) provided by a large hospice provider in South East England was evaluated (2010) to provide evidence of impact on achieving ...
Holdsworth, LM, Caragh Flannery, Flannery, C, Butler, C, Gage, Heather, Heather Gage, Flannery, Caragh, Laura M. Holdsworth, Williams, P, Claire Butler, Holdsworth, Laura M., Williams, Peter, Peter Williams, Butler, Claire   +13 more
core   +2 more sources

Leptomeningeal Carcinomatosis: A Diagnosis Challenge

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Leptomeningeal carcinomatosis (LC) in patients with disseminated cancer has a grave prognosis and limited therapeutic options. Diagnosis is delayed due to low CSF volume and scant cellularity. This quality improvement project was undertaken to evaluate the diagnostic performance of CSF cytology in cases with radiologic evidence and ...
Makayla Hyde, Christine F. Lauro, Aaron McConeghey, Laurentia Nodit   +3 more
wiley   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Impact of Surgical Airways on Location of Death, Healthcare Utilization, and Costs Among Patients With Head and Neck Cancer: A Population‐Based Study

Head &Neck, EarlyView.
ABSTRACT Background Patients with surgical airways experience barriers to high quality end‐of‐life (EOL) care. Recognizing differences in healthcare utilization and location of death among patients with surgical airways may inform improvements in EOL care delivery.
A. Travis Pickett, Colleen Webber, Michael Pugliese, Katie Dover, Angelina Tohme, Stephanie Johnson‐Obaseki, Peter Tanuseputro   +6 more
wiley   +1 more source