Results 81 to 90 of about 4,912,407 (281)

Vitamin D supplementation in individuals with type 1 diabetes mellitus (T1DM): a systematic review and meta-analysis focusing on pediatrics

Diabetology & Metabolic Syndrome
Backgrounds Type 1 diabetes mellitus (T1DM) is a significant global health concern, particularly among pediatric populations. Emerging evidence suggests that vitamin D supplementation may support glycemic control in individuals with T1DM; however ...
Sen Fan, Tingting Zhang, Liyan Yin
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Elevated postoperative serum procalcitonin is not indicative of bacterial infection in cardiac surgical patients

Annals of Cardiac Anaesthesia, 2015
Background: Identifying infections early, commencing appropriate empiric antibiotic not only helps gain control early, but also reduces mortality and morbidity. Conventional cultures take about 5 days to identify infections.
Murali Chakravarthy, Deepak Kavaraganahalli, Sumant Pargaonkar, Rajathadri Hosur, Chidananda Harivelam, Ashwin Bharadwaj, Aditi Raghunathan   +6 more
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit

, 2017
BACKGROUND: Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized.
Loeches, I. M., Marín Corral, Judith, Barbadillo, Sandra, Rodríguez, Alejandro, Vilà Vilardell, Clara, González de Molina, Francisco Javier, Álvarez Lerma, Francisco, H1N1 GETGAG/SEMICYUC Study Group, Masclans Enviz, Joan Ramon   +8 more
core   +1 more source

How do hospital professionals involved in a randomised controlled trial perceive the value of genotyping vs. PCR-ribotyping for control of hospital acquired C. difficile infections? [PDF]

, 2014
Background: Despite scientific advances in typing of C. difficile strains very little is known about how hospital staff use typing results during periods of increased incidence (PIIs). This qualitative study, undertaken alongside a randomised controlled
Peter M Hawkey, Hawkey, Peter M., Szczepura, Ala, Parsons, Helen, Katherine Hardy, Susan Manzoor, Gossain, Savita, Savita Gossain, Hardy, K. (Katherine), Stallard, Nigel, Nigel Stallard, Manzoor, Susan, Ala Szczepura, Hardy, Katherine, Helen Parsons, Hawkey, P. M. (Peter M.), Szczepura, Ala; id_orcid   +16 more
core   +2 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

From Screening to Strategy: Targeted Carbapenem‐Resistant Enterobacteriaceae (CRE) Infection Prediction After Endoscopic Retrograde Cholangiopancreatography (ERCP)

Infection and Drug Resistance
Jundi Wang,1 Kaisheng Su,1 Shuying Wang,2,3 Yanfei Yang2 1Department of Rheumatology and Immunology, Hangzhou First People’s Hospital Affiliated of Westlake University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Wang J, Su K, Wang S, Yang Y
doaj