Results 61 to 70 of about 4,912,407 (281)

Invasive Bacterial Co-infection in African Children with Plasmodium falciparum Malaria: A Systematic Review. [PDF]

, 2014
Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome.
Maitland, Kathryn, Church, James, Church, K, James Church, Kathryn Maitland   +4 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Application of agent-based simulation to the modelling and management of hospital-acquired infections [PDF]

Hospital-acquired infections (HAIs) are a big threat to the well-being of patients and place a heavy burden on hospital resources. The thesis provides the first attempt to apply agent-based simulation (ABS) to describe the transmission dynamics and ...
Meng, Yang
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis

BMC Pediatrics
Background The current evidence regarding the impact of probiotics on diarrhea and constipation outcomes in children is inconclusive. This umbrella review of systematic reviews and meta-analyses aims to deliver a comprehensive and conclusive summary of ...
Le Chen, Yan Wang, Xiao Liu, Haioun Wong, Chengjiao Huang   +4 more
doaj   +1 more source

Point-prevalence survey of hospital acquired infections in three acute care hospitals in Northern Nigeria

Antimicrobial Resistance and Infection Control, 2020
Background Effective infection prevention and control strategies require reliable data describing the epidemiology of hospital acquired infections (HAIs), and this is currently lacking in Nigeria.
Usman Abubakar
doaj   +1 more source

Monitoring Quality of Care Through Linkage of Administrative Data: National Trends in Bloodstream Infection in U.K. PICUs 2003-2012. [PDF]

, 2015
OBJECTIVES Interventions to reduce hospital-acquired bloodstream infection have succeeded in reducing rates in U.S. PICUs, but there is a lack of evidence for the impact of similar interventions in the United Kingdom.
Tibby, Shane M, Muller-Pebody, Berit, Wade, Angie, Parslow, Roger, Mok, Q, Gilbert, R, Muller-Pebody, B, Parslow, R, Harron, Katie, Harron, K, Wade, A, Tibby, SM, Mok, Quen, Gilbert, Ruth   +13 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Hospital Acquired Infections

RCSB Protein Data Bank
Hospital-acquired infections represent one of the greatest challenges to patient safety and the quality of healthcare due to their direct association with increased morbidity and mortality, longer hospital stays, and higher healthcare costs. This study aims to identify, through a literature review, the main challenges, causes, and prevention strategies
Marise Oliveira da Costa, Gláucia Carvalho Deus, Andréa Lopes Orfão, Moacyr Starich Guerra Barreto, Felipe Areias Mourão, Eluananda Borges Rodrigues, Sabrina Ferreira Moreira   +6 more
  +5 more sources