Results 71 to 80 of about 3,337,856 (280)

Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines [PDF]

, 2005
Objective: Physicians frequently deviate from guidelines that promote prudent use of antimicrobials. We explored to what extent patient and disease characteristics were associated with compliance with guideline recommendations for three common infections.
Gans, ROB; id_orcid, Mol, PGM; id_orcid, Wieringa, Jaap E., Denig, P., Laseur, M., Haaijer-Ruskamp, F.M., Mol, Peter G. M.; id_orcid, Mol, PGM, Degener, JE, NannanPanday, P.V., Laseur, M, Denig, P; id_orcid, Wieringa, J.E., Haaijer-Ruskamp, Flora M., Mol, Peter G. M., Denig, P, NannanPanday, PV, Gans, ROB, Degener, John E., Mol, P.G.M., Gans, Rijk O. B., Gans, Rijk O. B.; id_orcid, Gans, R.O.B., Haaijer-Ruskamp, FM, Degener, J.E.   +24 more
core   +2 more sources

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Current Status and Future Perspectives of Robotic Surgery for Esophagogastric Cancer in Asia

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Robotic‐assisted surgery (RAS) has moved from an experimental adjunct to an increasingly established component of gastrointestinal (GI) oncological practice in parts of Asia, a region that carries a disproportionately high burden of gastric and esophageal cancer. Asian surgeons have been among the earliest and most prolific contributors to the
Jia Jun Ang, Jimmy Bok Yan So
wiley   +1 more source

Oropharyngeal irrigation to prevent ventilator-associated-pneumonia: Comparing potassium permangenate with chlorhexidine

International Journal of Preventive Medicine, 2018
Background: Pneumonia is one of the most common hospital-acquired infections among bedridden patients in Intensive Care Units (ICUs). Colonization of mouth and pharynx by pathogenic bacteria and their aspiration into the lower respiratory tract is an ...
Mohsen Meidani, Farzin Khorvash, Saeed Abbasi, Masoumeh Cheshmavar, Hossein Tavakoli   +4 more
doaj   +1 more source

Clinical utility of pharyngeal high‐resolution manometry with impedance for upper esophageal sphincter dysfunction in gastroenterology

Advances in Digestive Medicine, EarlyView.
Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar, Taher Omari, Michal Szczesniak, Chien‐Lin Chen, Richard Heddle, Charles Cock   +5 more
wiley   +1 more source

Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data [PDF]

, 2012
Triage tools have an important role in pandemics to identify those most likely to benefit from higher levels of care. We compared Community Assessment Tools (CATs), the CURB-65 score, and the Pandemic Medical Early Warning Score (PMEWS); to predict ...
Read, R. C., Openshaw, Peter J.M., Semple, Malcolm G., Lim Wei Shen, Semple, MG, Nicholson, K.G., Bannister Barbara, Taylor, B. L., Taylor Bruce L., Puja R. Myles (145227), Read Robert C., Brett, S.J., Semple, M. G., Wei Shen Lim (145243), Semple, M.G., Semple Malcolm G., Karl G. Nicholson (145257), Myles Puja R., Bannister, Barbara, Brett, S. J., Nguyen-Van-Tam, Jonathan S., Stephen J Brett, Jonathan S. Nguyen-Van-Tam (145263), Peter J M Openshaw, Lim, W.S., Taylor, B.L., Myles, P.R., Myles, PR, Barbara Bannister, Jonathan S Nguyen-Van-Tam, James McMenamin (145252), Brett, SJ, Puja R Myles, James McMenamin, Lim, W. S., Brett Stephen J., Nguyen-Van-Tam, JS, Enstone Joanne E., Karl G Nicholson, Wei Shen Lim, Nicholson, Karl G., Enstone, Joanne E., Openshaw Peter J. M., Enstone, J.E., Enstone, J. E., Robert C Read, Stephen J. Brett (145230), Brett, Stephen J., Lim, Wei Shen, McMenamin, J., Bruce L Taylor, Read, Robert C., Read, RC, Peter J. M. Openshaw (145235), McMenamin, J, Myles, Puja R., Joanne E Enstone, Enstone, JE, Nguyen-Van-Tam, J.S., Myles, P. R., Nicholson, KG, Robert C. Read (145234), Read, R.C., Malcolm G Semple, Malcolm G. Semple (80199), Lim, WS, Taylor, BL, Nicholson, K. G., Nguyen-Van-Tam Jonathan S., McMenamin, James, Bruce L. Taylor (145248), Barbara Bannister (145260), Drews, S.J., Nguyen-Van-Tam, J. S., Taylor, Bruce L., Bannister, B., Nicholson Karl G., Openshaw, P. J. M., McMenamin James, Openshaw, PJM, Joanne E. Enstone (145232), Openshaw, P.J.M., Bannister, B   +82 more
core   +1 more source

Phase II Study of Posttransplant Cyclophosphamide‐Based Graft‐Versus‐Host Disease Prophylaxis After HLA‐Mismatched Unrelated Donor Reduced Intensity Transplantation: Results From the ACCESS Trial Expansion Cohort

American Journal of Hematology, EarlyView.
ABSTRACT Posttransplant cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD) improves outcomes in recipients of HLA mismatched unrelated donor (MMUD) allogeneic hematopoietic cell transplantation (allo HCT). Outcomes of MMUD HCT using PTCy in patients requiring reduced intensity or non‐myeloablative conditioning (RIC/NMA) are not well ...
Brian C. Shaffer, Monzr M. Al Malki, Antonio Martin Jimenez Jimenez, Joseph Stanek, Stephanie Bo‐Subait, Brent R. Logan, Jianqun Kou, Erin Leckrone, Heather E. Stefanski, Stephen R. Spellman, Craig Malmberg, Medhat Askar, Rachel Cusatis, Dipenkumar Modi, Farhad Khimani, Mehdi Hamadani, Martin Maiers, Rachel Cook, Karen Ballen, Javier Bolaños‐Meade, Uttam Rao, Jordan Milner, Ramzi Abboud, Katarzyna Jamieson, George Carrum, Bhagirathbhai Dholaria, William J. Hogan, Ran Reshef, Satyajit Kosuri, Alison Loren, Karilyn Larkin, Sally Arai, Muna Qayed, Sung Won Choi, Larisa Broglie, Jeffery J. Auletta, Bronwen E. Shaw, Steven M. Devine, Mahasweta Gooptu   +38 more
wiley   +1 more source

Hospital-Acquired Pneumonia

, 2022
Pneumonia acquired during hospitalization is called nosocomial pneumonia (NP). Nosocomial pneumonia is divided into two types. Hospital-acquired pneumonia (HAP) refers to hospital-acquired pneumonia, whereas ventilator-associated pneumonia (VAP) refers to ventilator-associated pneumonia. Most clinical literature stresses VAP’s importance and associated
openaire   +1 more source