Results 51 to 60 of about 2,764 (222)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Clinical and epidemiological characteristics of users of Day Hospital

Revista de Enfermagem da UFPI, 2020
DOI: https://doi.org/10.26694/reufpi.v3i4.2377 Objetivo: Investigar o perfil clínico e epidemiológico dos pacientes internados no Hospital-Dia de Picos-PI.
Luisa Helena de Oliveira Lima, Maurício Santos de Sousa, Mário José de Sousa Neto, Rouslanny Kelly Cipriano de Oliveira, Naiara Durvalina da Luz
doaj  

Histovariability and fossil diagenesis of Pissarrachampsa (Pseudosuchia, Notosuchia, Baurusuchidae) from the Upper Cretaceous of Southeast Brazil

The Anatomical Record, EarlyView.
Abstract Notosuchians were key components of western Gondwanan Cretaceous ecosystems in terrestrial predator niches and exhibited remarkable taxonomic and ecological diversity. Previous research has explored their physiology, metabolism, and histology, revealing varied growth patterns and life history strategies.
Tito Aureliano, Virgínia Maciel, Pedro Victor Buck, Felipe C. Montefeltro, Thiago da S. Marinho, Aline M. Ghilardi   +5 more
wiley   +1 more source

Défice de alfa-1 antitripsina. A experiência do Hospital de Pulido Valente com a terapêutica de reposição

Revista Portuguesa de Pneumologia, 2009
Resumo: A alfa-1 antitripsina (AAT) é sintetizada pelo fíga-do, com uma semivida plasmática de 4-5 dias. Apresenta acção inibidora das proteases, com particular afinidade para a elastase dos neutrófilos.
Carla Alves Costa, Cristina Santos
doaj   +1 more source

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, EarlyView.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Hospital-dia da Faculdade de Medicina de Botucatu - Unesp: estudo descritivo da população atendida [PDF]

Interface - Comunicação, Saúde, Educação, 1999
Nos ultimos anos, a assistencia psiquiatrica em geral e os hospitais psiquiatricos, em particular, tem sido muito criticados. Como alternativa a hospitalizacao fechada, hospitais-dia (HD) e similares vem sendo criados. Dados do Ministerio da Saude do Brasil mostram um aumento do numero desses servicos, nao havendo, contudo, informacoes disponiveis ...
openaire   +4 more sources

TWEAK/Fn14 signaling drives oxidative cardiac injury in systemic lupus erythematosus: Evidence from patient biomarker studies, lupus mouse models, and cardiomyocyte assays

Arthritis &Rheumatology, Accepted Article.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/Fn14 signaling in SLE‐related cardiomyopathy and its potential as a ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Understanding the influence of transfusion and blood loss on tranexamic acid concentration in scoliosis surgery with blood loss

British Journal of Clinical Pharmacology, EarlyView.
Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá, Luisa Barreiros, Marcela A. Segundo, Eugénia Cruz, Sibylle Langenecker   +4 more
wiley   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source