Results 61 to 70 of about 3,003,161 (278)

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Hospital de día pediátrico polivalente. Experiencia en los primeros tres años.

Revista del Hospital de Niños, 2023
Introducción: El hospital de día unifica ventajas del diagnóstico y tratamiento ambulatorio con recursos terapéuticos de una internación convencional. Objetivo: Mostrar la experiencia del HDDP, en una institución privada.
Vanina Molea Citate, María Fernanda Romé, Nadia Pauselli, Natalia Todaro Kycila, Manuel Pavesse, Carolina Preti, Alejandro Ellis   +6 more
doaj   +2 more sources

Myiasis caused by Dermatobia Hominis: case report

Archivo Médico de Camagüey, 2021
Background: myiasis is any condition caused by larval stages of different types of diptera, which attack tissues and organs of vertebrate animals. The diptera Dermatobia hominis is located geographically in the territories corresponding to South America,
Alan Rafael García-Yánez, Mishel Stefania Arboleda-Carvajal   +1 more
doaj  

Habilidades cognitivo-linguísticas e sua relação com características respiratórias

Revista CEFAC, 2013
OBJETIVO: relacionar características respiratórias com o desempenho em habilidades cognitivo-linguísticas de crianças de uma escola pública da grande Belo Horizonte. MÉTODO: estudo transversal, observacional e descritivo.
Tatiana Vargas de Castro Perilo, Cecília Santos Freitas, Natália Cotta Cardoso, Andréa Rodrigues Motta, Luciana Mendonça Alves   +4 more
doaj   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Modbury Hospital Foundation brochure

Brochure for the Modbury Hospital ...
Modbury Hospital
core   +1 more source

Hospital day: (re)construction advances and new perspectives

Revista de Enfermagem da UFPI, 2020
DOI: https://doi.org/10.26694/reufpi.v4i3.3125 Objetivos: discutir os avanços e dificuldades enfrentadas pela equipe de saúde em um Hospital-Dia e identificar a atuação dos familiares em conjunto com a equipe multidisciplinar no tratamento de ...
Márcia Astrês Fernandes, Lucíola Galvão Gondim Corrêa Feitosa, Dilson Ruben de Macêdo Filho, Aline Raquel de Sousa Ibiapina, Lara Emanueli Neiva de Sousa, Ilana Maria Lobão Corrêa Feitosa
doaj  

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Modbury Hospital Foyer shot

Black and White photograph of the Modbury Hospital main ...
Modbury Hospital
core   +1 more source