Results 51 to 60 of about 3,003,161 (278)
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
, 1978 Black and white photos of the developments of Modbury Hospital in August ...
Modbury Hospital
core +1 more source
O OLHAR DA FAMÍLIA SOBRE O MANEJO DE UM HOSPITAL DIA EM SAÚDE MENTAL
Revista Portuguesa de Enfermagem de Saúde Mental, 2017 CONTEXTO: No tratamento das pessoas com transtorno mental é fundamental o apoio da família e da comunidade. De um lado, as terapias de suporte à família para a compreensão do fenômeno do adoecimento, desmistificando a doença e as suas formas de tratamento e, de outro, os mecanismos de estímulo às redes sociais de apoio, como formas de amparo na ...
Weber,César Augusto Trinta +1 more
openaire +2 more sources
Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
Advanced Science, EarlyView.PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan +18 more
wiley +1 more source
Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2
Advanced Science, EarlyView.Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang +15 more
wiley +1 more source
Advanced Science, EarlyView.An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai +10 more
wiley +1 more source
Advanced Science, EarlyView.Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang +17 more
wiley +1 more source
Debates em PsiquiatriaSumário Apresentação Capítulo 1. Intervenções terapêuticas: uma nova via em psiquiatria? Capítulo 2. Psiquiatria intervencionista: proposta curricular mínima Capítulo 3.
Heloisa Tartari Liberato Fernandes +1 more
doaj +1 more source
Incidência de infecção de sítio cirúrgico em hospital dia: coorte de 74.213 pacientes monitorados [PDF]
Revista SOBECC, 2019 Objetivos: Descrever a incidência de infecção do sítio cirúrgico (ISC) em seguimento após alta em hospital dia (HD) e comparar esses indicadores com dados de hospitais convencionais. Método: Estudo de coorte histórica composto de 74.213 pacientes operados e monitorados num HD de Salvador (BA), entre 2012 e 2017.
Eliana Auxiliadora Magalhães Costa +2 more
openaire +1 more source