Results 101 to 110 of about 15,847,430 (379)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. diez y siete

Revista de la Facultad de Medicina, 1955
C. E. M. 45 años. Ciudad de origen y procedencia: Umbita. Servicio del Profesor Piñeros Suárez. NOTA CLINICA: el enfermo ingresa al Servicio de Clínica  Quirúrgica el 22 de Noviembre de 1951, por presentar disfagia no dolorosa tanto para sólidos como ...
San Juan de Dios Hospital
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. veintitres

Revista de la Facultad de Medicina, 1955
Se hace una revisión de un caso clínico presentado en el Hospital San Juan de Dios, Bogotá.
Hospital San Juan de Dios
doaj  

Kidney disease is associated with in-hospital death of patients with COVID-19

Kidney International, 2020
Yi-chun Cheng, R. Luo, Kun Wang, Meng Zhang, Zhixian Wang, Lei Dong, Junhua Li, Ying Yao, S. Ge, Gang Xu   +9 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Conferencias anatomoclínicas: caso no. diez y ocho

Revista de la Facultad de Medicina, 1955
L. M. B. 16 años. Ciudad de Origen y Procedencia: Susa. Servicio del Prof. Manuel José Luque. NOTA CLINICA: La enferma ingresa al Servicio de Clínica Quirúrgica el 18 de enero de 1952, por presentar un bocio.
San Juan de Dios Hospital
doaj  

Barnes Hospital Bulletin [PDF]

, 1980
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1171/thumbnail ...

core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Conferencias anatomoclinicas: caso No. veintiuno

Revista de la Facultad de Medicina, 1955
M. del C. A. 40 años. Ciudad de origen: Zipaquirá. Procedencia Bogotá. Servicio del Profesor Rico. NOTA CLINICA: La paciente ingresa por primera vez al Hospital el 8 de octubre de 1951, por presentar episodios psicomotores diagnosticados inicialmente ...
San Juan de Dios Hospital
doaj