Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Arrested Coalescence: A Tool to Explore Tissue Rheology
BiophysicaTissue spheroids are self-organised 3D cellular aggregates that serve as a versatile platform in tissue engineering. While numerous high-throughput methods exist to characterise the cellular function of tissue spheroids, equivalent techniques for the ...
Sotiris Samatas +2 more
doaj +1 more source
An Eastern Hepatobiliary Surgery Hospital Microvascular Invasion Scoring System in Predicting Prognosis of Patients with Hepatocellular Carcinoma and Microvascular Invasion After R0 Liver Resection: A Large-Scale, Multicenter Study [PDF]
, 2019 Xiuping Zhang +14 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Improving hospital quality to reduce disparities in severe maternal morbidity and mortality
, 2017 Elizabeth A. Howell, Jennifer Zeitlin
openalex +2 more sources
Person-centered maternity care during childbirth and associated factors at selected public hospitals in Addis Ababa, Ethiopia, 2021: a cross-sectional study [PDF]
, 2022 Azezew Ambachew Tarekegne +2 more
openalex +1 more source
Barnes Hospital Bulletin [PDF]
, 1981 https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1188/thumbnail ...
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Prevalence of icaA and icaD Genes of Staphylococcus aureus and Staphylococcus epidermidis Strains Isolated from Patients and Hospital Staff [PDF]
, 2007 Sara E. Satorres, Lucía Esther Alcaráz
openalex +1 more source