Results 81 to 90 of about 709,319 (308)

Initial comparisons of modular-sized, integrated utility systems and conventional systems for several building types [PDF]

The results of a study of the application of a modular integrated utility system to six typical building types are compared with the application of a conventional utility system to the same facilities.
Benson, H. E., Monford, L. G., Jr.
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Research on Modular Space Design of Emergency Hospitals Based on BIM Technology Innovation

Buildings
In recent years, due to the COVID-19 pandemic and the impact of various natural disasters worldwide, the construction of emergency buildings, particularly emergency hospitals, has gained critical importance. This study explores methods for expediting the
Guangping Zhang, Jialei Sun
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Diseño y construcción del Hospital Infanta Leonor en Vallecas (Madrid) = Design and construction of the Infanta Leonor Hospital. Vallecas (Madrid) [PDF]

, 2010
El Hospital Infanta Leonor en Vallecas se ha planteado como una investigación sobre la nueva generación de hospitales flexibles, basada en los sistemas constructivos, buscando un diseño innovador como alternativa a los esquemas hospitalarios ...
Araujo Armero, Ramón
core   +1 more source

A simple novel device for air sampling by electrokinetic capture. [PDF]

, 2015
BackgroundA variety of different sampling devices are currently available to acquire air samples for the study of the microbiome of the air. All have a degree of technical complexity that limits deployment.
Frazier, Angel, Gandhi, Prasanthi, Gilbert, Jack A, Gordon, Julian, Hampton-Marcell, Jarrad, Shekhawat, Gajendra   +5 more
core   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

The East Baltimore Revitalization Initiative: A Commitment to Economic Inclusion [PDF]

, 2011
Describes the first phase of a twenty-year, cross-sector effort to transform a distressed neighborhood into a mixed-income residential community and provide job opportunities for minorities and women; achievements to date; challenges; and lessons ...

core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source