Results 151 to 160 of about 4,976,545 (265)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Modbury Hospital Annual Report 1997 2

, 1997
Copy of the 1997 Modbury Hospital Annual Report.
Modbury Hospital
core  

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Modbury Hospital Site photo

Black and white photo of the Modbury Hospital site from an overhead view.
Modbury Hospital
core   +1 more source

Agricultural Diversification at the Margin. Strategies and Determinants in Italian Mountain and Remote Areas

Agribusiness, EarlyView.
ABSTRACT This paper explores the convergence in on‐farm diversification strategies of agricultural holdings, between remote areas and more central ones. Using Italian farm‐level data, we explore the determinants of diversification strategies across farms.
Gianluca Grilli, Francesco Pagliacci, Paola Gatto   +2 more
wiley   +1 more source

The relationship between hospital ethical climate and continuing education in nursing ethics

, 2023
openaire   +1 more source

Modbury Hospital Annual Report 1991-1992

, 1991
Annual newsletter concerned with Modbury ...
Modbury Hospital
core  

One‐Year Healthcare Utilization and Costs After Emergency Department Encounters for Uncomplicated Appendicitis: A Statewide Observational Study

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective Non‐operative management with antibiotics has emerged as an alternative to appendectomy for uncomplicated appendicitis. This study compared one‐year healthcare costs and utilization outcomes after operative versus non‐operative management of uncomplicated appendicitis using statewide administrative data.
Andrew C. Meltzer, Michael Makutonin, Taylor Gorak, Aditya Loganathan, Jack A. Meltzer, Avi Dor   +5 more
wiley   +1 more source

Reduced‐Port Versus Multi‐Port Laparoscopic Colectomy for Colorectal Cancer: A Systematic Review, Meta‐Analysis, and Meta‐Regression

Annals of Gastroenterological Surgery, EarlyView.
Reduced‐port laparoscopic colectomy (RPLC) for colorectal cancer offers modest intraoperative benefits, including shorter operative time and lower blood loss, while maintaining comparable postoperative recovery, lymph node yield, and complication rates to multi‐port laparoscopic colectomy (MPLC).
Ayesha Shaukat, Saad Ashraf, Hamza Irfan, Muhammad Shahmeer Ullah Shah, Yumna Khabir, Santosh Sah, Um E. Abiha Batool, Muhammad Zain Ul Haq, Omer Bin Khalid Jamil, Aymar Akilimali   +9 more
wiley   +1 more source