Results 91 to 100 of about 16,676,610 (248)

Transformative model of medical education [PDF]

Journal of Krishna Institute of Medical Sciences University
The 'Western Medicine' came to India through th Portuguese in early 16 Century. However, it was not institutionalized in a concrete sense until British East India Company constructed hospital at Madras followed by Surat and Machhalipattam, which were ...
Vedprakash Mishra
doaj  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

พิพิธภัณฑ์ศิริราช

, 2014
A plot of land located at the south of the Bangkok Noi estuary has been engraved with the past glories of the Ayutthaya Kingdom, and it became a part of the northern fortresses during the Thonburi Dynasty. After the establishment of the Chakri Dynasty in
Mahidol University. Faculty of Medicine Siriraj Hospital. Siriraj Museum Unit.
core  

Primary bone lymphoma presenting as fever of unknown origin

Journal of General and Family Medicine, 2022
Yuki Otsuka, Yasuhiro Nakano, Daisuke Omura, Kou Hasegawa, Fumio Otsuka   +4 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

A Questionnaire Study of Leadership in General Medicine: General Physicians in Japan are Facing Challenges in Education and Research [Response to Letter]

International Journal of General Medicine
Risa Hirata,1 Masaki Tago,1 Hiromizu Takahashi,2 Takashi Watari,3 Kiyoshi Shikino,4,5 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine, Faculty of Medicine, Juntendo ...
Hirata R, Tago M, Takahashi H, Watari T, Shikino K, Sasaki Y, Shimizu T   +6 more
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Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Precise Classification of Generalists is Necessary to Establish Evidence in General Medicine [Response to Letter]

International Journal of General Medicine
Risa Hirata,1 Masaki Tago,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine, Chiba University Hospital, Chiba,
Hirata R, Tago M, Shikino K, Watari T, Takahashi H, Sasaki Y, Shimizu T   +6 more
doaj  

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

How Do We Establish the Utility and Evidence of General Medicine in Japan?

International Journal of General Medicine
Masaki Tago,1 Risa Hirata,1 Hiromizu Takahashi,2 Shun Yamashita,1,3 Masayuki Nogi,4,5 Kiyoshi Shikino,6 Yosuke Sasaki,7 Takashi Watari,8 Taro Shimizu9 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine,
Tago M, Hirata R, Takahashi H, Yamashita S, Nogi M, Shikino K, Sasaki Y, Watari T, Shimizu T   +8 more
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