Results 101 to 110 of about 947,668 (293)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Finnish Journal of eHealth and eWelfare, 2016 This paper outlines a practical approach for enabling user-centric healthcare information systems development in large scale. The approach is especially powerful at the current stage of clinical informatics adoption by the leading countries which have ...
Janne Pitkänen, Matti Pitkäranta
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The Relationship between Management Information Systems and Green Supply Chain Management: Green Service Supply Chain Management for Performance Enhancement in Hospitals [PDF]
, 2023 Hend E. Allam +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
, 2020 This thesis investigates hospital information system. The traditional systems were found to be completely manual and subject to numerous problems like duplication, loss of records, huge storage space and time consuming. A through study on the modern computerized hospital information systems is made and their main features discussed.
openaire +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Do Hospital Information Systems Vendors Meet User Needs?
مدیریت اطلاعات سلامت, 2011 • Introduction: Since users have a critical role in the success of a hospital information system, and also considering software companies as information system service providers-not only product sellers, this study was conducted to evaluate the hospital ...
Mehrdad Farzandipour, Zahra Meidani
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