Results 121 to 130 of about 2,190,948 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparing the Laboratory module of Hospital Information System software in Hospitals of Isfahan University of Medical Sciences, based on the International standard ISO 9241-110

مدیریت اطلاعات سلامت, 2015
Introduction: Hospital information systems are one of the most important systems in improving the quality of health care. Because of the enormous costs that would be spent for installation and implementation of health information systems, it is important
Mohammad Mahmoudi Maymand, Tahere Yaghoobi, Parnaz Naghdi sede   +2 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Usability Evaluation of Hospital Information Systems Based on Isometric Standard from the Viewpoint of Usersin Education and Treatment Centers Affiliated to Qom University of Medical Sciences, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Background and Objectives: Evaluation has an important role in software development. Quality is considered in the evaluation of information systems, which depends on usability, availability, validity, compatibility, and response time.
Atefeh Mousavi, Maryam Hemati, Saeid Kayyal, Ahmadreza Shamshiri   +3 more
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Penggunaan Metode Tcsd (Task Centered System Design) Dalam Website Rekam Medis Pada Rumah Sakit Pelabuhan Palembang [PDF]

, 2016
Pelabuhan Hospital Palembang is one of the institutions of public health services in Palembang located at Jalan Mayor Memet Sastrawirya No.1, Palembang.
Muzakir, A. (Ari), Sopiah, N. (Nyimas)
core  

Analysis of the Spectrum and Characteristics of Pediatric Cancer Based on Hospital Information Systems in China. [PDF]

Cancer Manag Res, 2021
Zhou H, Wu Z, Wang H, Yu W, Huang J, Zhou L, Yu D, Hou T, Lv Y, Chen C, Luo L, Shi J, Wang Z.   +12 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improving meaningful use and user experience of healthcare information systems towards better clinical outcomes

Finnish Journal of eHealth and eWelfare, 2016
This paper outlines a practical approach for enabling user-centric healthcare information systems development in large scale. The approach is especially powerful at the current stage of clinical informatics adoption by the leading countries which have ...
Janne Pitkänen, Matti Pitkäranta
doaj  

Ipteks Faktor – Faktor Penghambat Proses Pelaporan Data Sistem Informasi Rumah Sakit (Sirs) Berbasis Online pada Rsup Prof. Dr. R. D. Kandou Manado [PDF]

, 2018
According to Permenkes Republic of Indonesia Number 1171 / MENKES / PER / VI / 2011 concerning SIRS that every hospital is required to implement an online hospital information system to improve the quality of services to hospitals. But in this case there
Kalalo, M. Y. (Meily), Taroreh, L. (Lyviani)   +1 more
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