Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Finnish Journal of eHealth and eWelfare, 2016 This paper outlines a practical approach for enabling user-centric healthcare information systems development in large scale. The approach is especially powerful at the current stage of clinical informatics adoption by the leading countries which have ...
Janne Pitkänen, Matti Pitkäranta
doaj
Scalable and Interoperable Platform for Precision Medicine: Cloud-based Hospital Information Systems. [PDF]
Healthc Inform Res, 2022 Jang JS, Kim N, Lee SH.
europepmc +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Current landscape of hospital information systems in gynecology and obstetrics in Germany: a survey of the commission Digital Medicine of the German Society for Gynecology and Obstetrics. [PDF]
Arch Gynecol Obstet, 2023 Pfob A +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Development and Application Evaluation of a Nursing Simulation Teaching Information System Based on Hospital Information Systems. [PDF]
Int J Clin Pract, 2023 Zhang L +7 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
User participation and user satisfaction in information systems development [PDF]
, 2001 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 26/06/2001.Information Systems (IS) are being developed and used in organizations to achieve their business goals and to enhance organizational ...
Bokhari, Rahat Hussain
core +2 more sources
Factors Influencing Clinicians' Use of Hospital Information Systems for Infection Prevention and Control: Cross-Sectional Study Based on the Extended DeLone and McLean Model. [PDF]
J Med Internet Res, 2023 Zheng F +8 more
europepmc +1 more source