Results 181 to 190 of about 137,898 (253)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Frequent Detection of HIV-1 Variants With Mixed Coreceptor Usage Among People Who Inject Drugs Infected With CRF01_AE: Possible Association With Coreceptor Switch. [PDF]

Open Forum Infect Dis
Maeda Y, Chikata T, Kuwata T, Terasawa H, Van Tran G, Matsushita S, Sawa T, Hasebe F, Takiguchi M.   +8 more
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Systematic librarian-led zip code analysis to target underserved communities. [PDF]

J Med Libr Assoc
Roberts R, Grabeel KL.
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Rapid Nanopore Sequencing of Positive Blood Cultures Using Automated Benzyl-Alcohol Extraction Improves Time-Critical Sepsis Management. [PDF]

Antibiotics (Basel)
Tai CS, Chung HY, Lin TH, Chang CK, Perng CL, Hsieh PS, Shang HS, Jian MJ.   +7 more
europepmc   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement. [PDF]

NPJ Genom Med
Batlle-Masó L, Padrosa Pulido J, Esteve-Codina A, Perurena-Prieto J, Franco-Jarava C, Aguiló-Cucurull A, Martínez-Gallo M, Cea C, Rodriguez-Aliberas M, Soler-Palacín P, Casals F, Redondo Velao S, Torrent M, Alsina L, Colobran R.   +14 more
europepmc   +1 more source

First draft genome sequence of <i>Candidozyma auris</i> from a human clinical isolate in a major metropolitan hospital in Lima, Peru. [PDF]

Microbiol Resour Announc
Cuicapuza D, Soto-Febres F, Neyra E, Bustamante B.   +3 more
europepmc   +1 more source

Clinical Characteristics and Molecular Profiling of <i>SF3B1</i>-Mutated Myelodysplastic Syndrome (MDS) in a Real-World Practice. [PDF]

Int J Mol Sci
Wang RR, Than H, Tham C, How GF, Khoo SJ, Tuy TT.   +5 more
europepmc   +1 more source