Results 231 to 240 of about 377,502 (296)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

A metrological foundation for absolute transcriptomics using International System of Units-anchored calibrators. [PDF]

Nat Commun
Zhang Y, Yang B, Yu Y, Wang X, Niu C, Zhang Y, Liu Y, Li J, Zhang C, Yang J, Tian J, Liu Z, Tang Z, Gao Y, Zheng Y, Liu Y, Xiao T, Zhang R, Fang X, Shi L, Dong L.   +20 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

A novel parvovirus circulating in canine populations and sporadically detected in human oropharyngeal samples. [PDF]

Microbiol Spectr
Lu X, Kong N, Wang C, Lu J, Li W, Yang H, Lu X, Zhang Z, Chen Y, Huang S, Zhou C, Zhang Y, Zhang W, Shan T.   +13 more
europepmc   +1 more source

Underestimation of Cardiovascular Risk by 2019 World Health Organization (WHO) Cardiovascular Risk Charts Compared With Framingham Global Risk Score (FGRS) in a Brazilian Population: Implications for Primary Prevention. [PDF]

Cureus
Teixeira da Matta Flora Neto A, Petraglia Barroso L, Rodrigues Fernandes L, O'Connell JL.   +3 more
europepmc   +1 more source

ECG-Based Prediction of Shock-Refractory Ventricular Fibrillation During Resuscitation Without Interrupting CPR. [PDF]

Circ Arrhythm Electrophysiol
Coult J, King JA, Kwok H, Kutz JN, Blackwood J, Boyle PM, Hsu CH, Daya MR, Johnson NJ, Kudenchuk PJ, Rea TD.   +10 more
europepmc   +1 more source

The specificity landscape of WRKY transcription factors reveals the bidirectional influence of non-CG methylation. [PDF]

Nucleic Acids Res
Ma N, Jiang D, Li T, Luo L, Chen H, Zhang X, Mu Z, Chen S, Chen P, Liu Q, Lin J, Wang Q, Yin Y, Taipale J, Huang J, Guo H, Zhu F.   +16 more
europepmc   +1 more source