Results 91 to 100 of about 460,810 (250)

An Ion‐Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR‐Mediated Antibacterial Activity of PEEK

open access: yesAdvanced Materials, EarlyView.
A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu   +7 more
wiley   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

open access: yesAdvanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon   +3 more
wiley   +1 more source

Scalable Task Planning via Large Language Models and Structured World Representations

open access: yesAdvanced Robotics Research, EarlyView.
This work efficiently combines graph‐based world representations with the commonsense knowledge in Large Language Models to enhance planning techniques for the large‐scale environments that modern robots will need to face. Planning methods often struggle with computational intractability when solving task‐level problems in large‐scale environments ...
Rodrigo Pérez‐Dattari   +4 more
wiley   +1 more source

Path planning for intelligent robots in hospital libraries based on deep learning

open access: yesDiscover Computing
Intelligent robots in hospital libraries assist students, physicians, and other users in the process of referring, documenting, and correcting teaching and diagnostic information.
Can Zhu, Rui Zhu, Cheng Yao
doaj   +1 more source

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

open access: yesAdvanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy   +13 more
wiley   +1 more source

Real‐Time Holographic Feedback via Mixed Reality Sensorized Laryngoscope Training System Enhances Pediatric Intubation Training

open access: yesAdvanced Robotics Research, EarlyView.
We proposed a Mixed Reality Sensorized Laryngoscope Training System to provide real‐time holographic torque feedback during pediatric endotracheal intubation simulation. Visualization formats are evaluated to reduce tracking error and visual demand.
Jiaqi Li   +5 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

open access: yesAdvanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu   +12 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

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