Results 61 to 70 of about 460,810 (250)

Coping with Impostor Feelings: Evidence Based Recommendations from a Mixed Methods Study

Evidence Based Library and Information Practice, 2020
Objective – The negative effects of impostor phenomenon, also called impostor syndrome, include burnout and decreased job satisfaction and have led to an increased interest in addressing this issue in libraries in recent years.
Jill Barr-Walker, Debra A. Werner, Liz Kellermeyer, Michelle B. Bass   +3 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Maternal prenatal systemic inflammation indexes predicts premature neonatal respiratory distress syndrome

Scientific Reports
Neonatal respiratory distress syndrome (NRDS) is one of the leading causes of neonatal mortality in low-income countries. It is caused by a lack of surface-active substances in the lungs, and the maternal inflammatory response plays an important role in ...
Mengqing Weng, Jie Wang, Jingfeng Yin, Liufang He, Han Yang, Huimin He   +5 more
doaj   +1 more source

Newsletter als reichweitenstarkes und effizientes Kommunikationsinstrument in der Online-Bibliothek einer Krankenhausgruppe – ein Erfahrungsbericht

GMS Medizin – Bibliothek – Information, 2016
For 7 years now, the approx. 6,000 employees of the Austrian hospital network “Vinzenz Gruppe” with 7 hospitals receive an email newsletter from their medical library every 1–2 months with topics ranging from directly library related content to a wider ...
Vogel, Christian
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Die Medizinische Zentralbibliothek und Patientenbibliothek des Klinikums Fulda – Service für Mitarbeiter und Patienten aus einer Hand /The Medical Center Library and Patient Library of the Hospital Fulda – service for staff and patients from a single source

GMS Medizin – Bibliothek – Information, 2011
1978 sees the establishment of a Medical Center Library (MedZB) to bring together hitherto scattered literature of the existing municipal clinics.Since the creation of a supplementary Patient Library in 1984, both libraries offer in common rooms at below
Nentwig,Dagmar
doaj  

Application of data mining for predicting hemodynamics instability during pheochromocytoma surgery

BMC Medical Informatics and Decision Making, 2020
Background Surgical resection of pheochromocytoma may lead to high risk factors for intraoperative hemodynamic instability (IHD), which can be life-threatening.
Yueyang Zhao, Li Fang, Lei Cui, Song Bai
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source