Results 61 to 70 of about 15,897,913 (288)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Modbury Hospital Site photos

open access: yes, 1978
Black and white photos of the developments of Modbury Hospital in August ...
Modbury Hospital
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Hospital Review photo

open access: yes, 1982
Colour photo of three nurses, two in costume, during the Hospital ...
Modbury Hospital
core   +1 more source

PENILAIAN BAHAN BERBAHAYA BERACUN PADA LABORATORIUM RADIOLOGI RSUD BANGIL KABUPATEN PASURUAN

open access: yesThe Indonesian Journal of Occupational Safety and Health, 2018
The consequence of activity in hospital is to produce toxic material waste (B3). So, description of B3 in the hospital was needed. The objective of this research was to identify the hazards in each stage in waste management of Liquid Hazardous and Toxic (
Frans Salesman, Umi Farida
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Planning for Hospital Pharmacy Management, Now and in the Future [PDF]

open access: yes, 2008
Where have all the pharmacy managers gone? This question has garnered the attention of hospital pharmacists across Canada in the wake of changing management roles, the appointment of nonpharmacist managers, and ongoing vacancies in formal leadership ...
Management Task Force, CSHP Hospital Pharmacy
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

Understanding occupational health challenges in managing hospital solid waste in Zimbabwe: a critical review

open access: yesDiscover Public Health
Industrialisation and service provision expose involved people to occupational health risks, including solid waste workers. In Zimbabwe, many concerns focus on occupational health risks affecting workers in industries, giving little attention to those ...
Steven Jerie   +4 more
doaj   +1 more source

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