Results 231 to 240 of about 1,547,276 (298)

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Standardizing postpartum family planning counseling guidance in Ghana: A stepped-wedge cluster randomized implementation effectiveness trial. [PDF]

PLoS One
Sonalkar S, Maya E, Guure C, McAllister A, Puplampu D, Doe R, Gallop R, Kiarie J, Gaffield ME.   +8 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

From Resection to Rehabilitation in One Day: Digital Workflow for Mandibular Reconstruction with Fibular Free Flap and Immediate Dental Rehabilitation Using CAD/CAM Guides at the Point of Care. [PDF]

Craniomaxillofac Trauma Reconstr
Ureel M, Denoiseux B, Brijs K, Boderé PJ, Dhooghe N, Coopman R.   +5 more
europepmc   +1 more source

Immediate postpartum family planning utilization and associated factors among postpartum mothers in South Ethiopia. [PDF]

Ann Med Surg (Lond)
Shate ME, Mesfin R.
europepmc   +1 more source

Strategies for Malar Implant Placement: A Review of Access, Planning, and Outcomes. [PDF]

Plast Reconstr Surg Glob Open
Kauke-Navarro M, Knoedler L, Klimitz FJ, Diatta F, Kong V, Bigus S, Alperovich M, Lellouch AG, Safi AF.   +8 more
europepmc   +1 more source

Dosimetric evaluation of biaxially rotational dynamic radiation therapy and swing-fixed non-coplanar volumetric modulated arc therapy with OXRAY in prostate cancer: a comparative study. [PDF]

Radiat Oncol J
Hirotaki K, Makita K, Tomizawa K, Wakabayashi M, Hojo H, Nakamura M, Ito M.   +6 more
europepmc   +1 more source

Utilizing and Optimizing Forecasting Models for Nursing Demand: A Narrative Review. [PDF]

Health Sci Rep
Singh K, Souza LAD, Nazarene A, Mounia A, Khedr MA, Mousa A, George RR, Nahwan AJ.   +7 more
europepmc   +1 more source

The role of 3D simulation and osteotomy guides in improving surgical outcomes for complex spinal deformities: a comparative study. [PDF]

BMC Musculoskelet Disord
Han C, Ding Z, Zhang Y, Liang W, Hai Y.
europepmc   +1 more source