Results 131 to 140 of about 1,953,126 (302)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies

Frontiers in Cardiovascular Medicine
BackgroundThe association between sarcopenia and risk of atrial fibrillation (AF) remains uncertain. In this study, we aimed to quantify the association between sarcopenia and the risk of AF through a meta-analysis of observational cohort studies ...
Jie Liu, Zhen Li, Yanhong Bi, Xiaoyu Che, Ao Feng, Yazhuo Liu, Yiou Wang, Simiao Tian   +7 more
doaj   +1 more source

Mental health outcomes before psychotropic medications: a retrospective case series of one state hospital records from 1945 to 1954. [PDF]

BMC Health Serv Res, 2023
Chapleau A, Harrison J, Love S, Sherman D.   +3 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Quality of Life of Multi Drug Resistant Tuberculosis Patients: a Study of North India

Acta Medica Iranica, 2014
Tuberculosis is still one of the leading causes of mortality and morbidity. Besides clinical impact, the disease affects the quality of life (QOL) too.
Raman Sharma, Ravinder Yadav, Meenakshi Sharma, Varinder Saini, Vipin Koushal   +4 more
doaj  

Impact of healthcare-associated infection on healthcare services and survival of patients with cancer: a propensity score-matched retrospective study

BMC Cancer
Background Healthcare-associated infections (HAI) lead to poor patient outcomes, including morbidity, mortality, length of hospital stay (LOS) and costs.
Changpeng Liu, Chunhua Song, Yijie Chen, Xi Li, Yamei Qiao, Xiaowen Zhang, Dongjian Yang, Hongshan Huang   +7 more
doaj   +1 more source

Difference in presentation, outcomes, and hospital epidemiologic trend of COVID-19 among first, second, and third waves: a review of hospital records and prospective cohort study. [PDF]

Ann Med Surg (Lond), 2023
Mahmud R, Islam MA, Haque ME, Hussain DA, Islam MR, Monayem FB, Kamal MM, Sina H, Islam MF, Datta PK, Sayeed SKJB, Dhali SA, Islam K, Ratul RH, Hossain SKMR, Prince HN, Chowdhury AH, Ahmed KGU, Miah MT, Rahman MM.   +19 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Data Analysis of COVID-19 Hospital Records Using Contextual Patient Classification System. [PDF]

Ann Data Sci, 2022
Gada V, Shegaonkar M, Inamdar M, Dinesh S, Sapariya D, Konde V, Warang M, Mehendale N.   +7 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source