Results 81 to 90 of about 88,107,133 (294)

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Coming home: older patients’ and their relatives’ experiences of well-being in the transition from hospital to home after early discharge

International Journal of Qualitative Studies on Health & Well-Being
Background This study aims to investigate the lived experience of well-being among older patients and their relatives in the transition from hospital to home after early discharge.
Aline Dragosits, Bente Martinsen, Ann Hemingway, Annelise Norlyk   +3 more
doaj   +1 more source

The transition of stroke survivors from hospital to home: Understanding work and design opportunities [PDF]

, 2017
A growing body of HCI research explores designs to support rehabilitation after stroke. While rehabilitation is a major part of a stroke survivor’s recovery, it is not the only part that could benefit from HCI work.
Bernd Ploderer, Muller, Jennifer, Jennifer Muller, Tran, Vivian, Green, Theresa L., Ploderer, Bernd, Theresa L. Green, Stuart, Jonathon, Jonathon Stuart, Vivian Tran   +9 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The Facilitators to Care Transition from Hospital to Home After Stroke: A Qualitative Study

Iranian Journal of Nursing and Midwifery Research
Background: Ineffective hospital-to-home care transition (HHCT) can lead to the early rehospitalization of patients with stroke (PWS). Therefore, effective HHCT management is essential to maintain patient safety and reduce rehospitalization.
Somayeh Bahadoram, Narges Arsalani, Masoud Fallahi-Khoshknab, Farahnaz Mohammadi-Shahbolaghi, Asghar Dalvandi   +4 more
doaj   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Modbury Hospital Exterior photo

, 1981
Black and white photo of the exterior of Modbury ...
Modbury Hospital
core   +1 more source

Modbury Hospital Emergency Room photo

, 1991
Black and white photo of patient and staff in the foyer to Modbury Hospital Emergency ...
Modbury Hospital
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

TRANSFER‐I: Hospitalised Older Adults and Their Carers' Perspectives of the Transition Home: A Qualitative Study

Health Expectations
Background Transitioning from hospital to home is a critical and fragmented process for acutely ill older adults and their carers. Despite widespread recognition of its importance, persistent gaps leave older adults vulnerable, highlighting the urgent ...
Kirsten J. Parker, Caleb Ferguson, Julee McDonagh, Richard Lindley, Louise D. Hickman   +4 more
doaj   +1 more source