Results 111 to 120 of about 270,120 (271)

Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness

Brain Stimulation, 2020
Enrique Noé, Joan Ferri, Carolina Colomer, Belén Moliner, Myrtha O'Valle, Patricia Ugart, Clara Rodriguez, Roberto Llorens, PhD   +7 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients

npj Breast Cancer
Early breast cancer patients often experience relapse due to residual disease after treatment. Liquid biopsy is a methodology capable of detecting tumor components in blood, but low concentrations at early stages pose challenges.
Alfonso Alba-Bernal, Ana Godoy-Ortiz, María Emilia Domínguez-Recio, Esperanza López-López, María Elena Quirós-Ortega, Victoria Sánchez-Martín, María Dunia Roldán-Díaz, Begoña Jiménez-Rodríguez, Jesús Peralta-Linero, Estefanía Bellagarza-García, Laura Troyano-Ramos, Guadalupe Garrido-Ruiz, M. Isabel Hierro-Martín, Luis Vicioso, Álvaro González-Ortiz, Noelia Linares-Valencia, Jesús Velasco-Suelto, Guillermo Carbajosa, Alicia Garrido-Aranda, Rocío Lavado-Valenzuela, Martina Álvarez, Javier Pascual, Iñaki Comino-Méndez, Emilio Alba   +23 more
doaj   +1 more source

Arquitectura española contemporánea. Algunos hospitales modernos [PDF]

, 1922
Arquitectura española contemporánea.
Torres Balbás, Leopoldo
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Dinámica empresarial en el sector nuclear: conocimiento y cultura de seguridad [PDF]

, 2016
Desde sus inicios el sector nuclear ha tenido muy en cuenta la teoría de sistemas (1975) dada la necesidad de control de los diferentes factores endógenos y exógenos.
Merino Moreno, Carlos
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

npj Parkinson's Disease
The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (SNc) is a critical and unresolved question in Parkinson´s disease.
Natalia López-González del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H. G. Monje, José L. Lanciego, Carmen Cavada, José A. Obeso, Javier Blesa   +10 more
doaj   +1 more source