Results 111 to 120 of about 4,574,187 (367)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Unidades de comunicación en los hospitales de la ciudad de Murcia: estatus, estrategias y tácticas [PDF]

open access: yes, 2005
Desde que la Administración decide promocionar a los médicos para la gestión de los hospitales las relaciones públicas empresariales cobran importancia en sus programas de calidad.
Montero del Amo, Beatriz
core  

Quality of life associated factors in Chileans hospitals nurses Factores asociados a calidad de vida de enfermeras hospitalarias chilenas Fatores associados a qualidade de vida de enfermeiras hospitalares chilenas

open access: yesRevista Latino-Americana de Enfermagem, 2007
This study is focused on knowing the Quality of Life of hospital nurses, and associated factors. People surveyed are composed of 100 female nurses from a hospital, eighth region, Chile.
Lenka Andrades Barrientos   +1 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

“EXPERIENCIA DE LA HISTERECTOMÍA COMO INDICACIÓN DE URGENTE DURANTE 14 AÑOS ( 1994- 2008 ) EN DOS HOSPITALES DE SEGUNDO NIVEL DE LA SECRETARÍA DE SALUD EN EL ESTADO DE MÉXICO”. [PDF]

open access: yes, 2013
Experiencia de la histerectomía como indicación de urgente durante 14 años (1994- 2008) en dos hospitales de segundo nivel de la secretaría de salud en el estado de ...
Murillo Camargo, Sofia   +1 more
core  

Sacral agenesis: a pilot whole exome sequencing and copy number study [PDF]

open access: yes, 2016
Background: Caudal regression syndrome (CRS) or sacral agenesis is a rare congenital disorder characterized by a constellation of congenital caudal anomalies affecting the caudal spine and spinal cord, the hindgut, the urogenital system, and the lower ...
Campbell, Desmond D.   +11 more
core   +1 more source

Epidemiología de la enfermedad ósea de Paget en un área de Barcelona

open access: yesRevista de Osteoporosis y Metabolismo Mineral, 2009
La enfermedad ósea de Paget (EP) es un trastorno focal, asintomática en la mayoría de los casos y de naturaleza desconocida. La epidemiología de esta enfermedad está poco caracterizada; se desconoce su prevalencia e incidencia globales en España.
Lisbona Pérez MP   +9 more
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Use of sugammadex on burn patients: descriptive study

open access: yesBrazilian Journal of Anesthesiology, 2015
Objectives: A burn patient is a challenge for any anesthesiologist, undergoing several surgeries during admission, and requiring general anesthesia and muscle relaxation most of the times.
Eduardo Rodríguez Sánchez M.   +3 more
doaj  

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